The problem of medical supply, rational and safe pharmacotherapy has become one of the most pressing in medical activity. Today the share of drug therapy in treatment measures reaches 95%. In some countries, the complications of pharmacotherapy take the fourth-sixth place in the structure of mortality, which is associated with the introduction in clinical medicine of a large number of drugs with high biological activity, sensitization of the population to biological and chemical substances, irrational use of drugs, the use of substandard drugs. The rational, effective and safe use of drugs using scientifically based approaches, the introduction of evidence-based medicine, pharmacoeconomic analysis requires the study of clinical pharmacology. The article emphasizes on the expediency of studying clinical pharmacology in the conditions of comorbid and polymorbid pathology, polypharmacy, gerontopharmacology, when prescribing antibacterial preparations of the reserve and other conditions that change the pharmacokinetics of drugs, as well as in suspicion of presence and/or detection of pharmacogenetic features of the patient. The study of clinical pharmacology should be linked to the development of a personalized medicine methodology that allows individualization of the choice of drugs, dosage regimens, taking into account the patient's characteristics, metabolism and transport systems status. The specialist in clinical pharmacology should know the holistic system of theoretical foundations of clinical pharmacology, factors that promote metabolism, the effects of drugs that increase the risk of side effects, based on the study and evaluation of pharmacokinetic parameters and pharmacodynamic effects of drugs; evaluation of the results of possible drug interactions; prediction and evaluation of drug efficacy; study of interrelation of pharmacokinetics and pharmacodynamics of pharmaceuticals; study of the features of pharmacokinetics and pharmacodynamics of drugs, depending on the functional state of the biological system of the body (age, pregnancy, etc.); ethical problems of clinical pharmacology; approbation and registration of new drugs that cause a large number of side effects; study and evaluation of information on achievements, mistakes, corrections, prospects of using medicines for the prevention, treatment and diagnosis of diseases. Conclusion. Clinical pharmacology is modern, clinically relevant, dynamic discipline. The issue of effective, high-quality and safe pharmacotherapy is one of the most important strategic goals of health care.
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