The article presents a retrospective review of professional foreign and domestic literature devoted to a topical multidisciplinary problem of hypothyroidism. The most commonly considered is the primary (thyrogenic) hypothyroidism, due to lesions of the thyroid gland itself. Material and methods. To present the acute problem of hypothyroidism we studied and analyzed 37 professional literary and scientific sources, 23of which were domestic and 14 were by foreign authors. Results and discussion. At primary hypothyroidism all types of metabolic processes are suppressed, oxygen utilization of tissues, oxidation reactions are inhibited, activity of various enzyme systems decreases, gas exchange and basic exchange. The study showed that an increase in peripheral vascular resistance occurs in the heart, lungs, kidneys, and serous cavities; develops hypercholesterolemia, hyperlipidemia, metabolic immunosuppression, functional disorders of the central nervous system. Loss of bone tissue, decrease in mineral density of bone, osteoporosis is negatively reflected on periodontal tissues. Studies of domestic and foreign authors proved that in the initial hypothyroidism all kinds of metabolic processes were suppressed, oxygen utilization by tissues, inhibitory oxidation reactions, decrease of activity of various enzyme systems, gas exchange, basic metabolism, mineral metabolism. In reducing the function of the thyroid gland, we observed suppression of nonspecific protective factors such as bactericidal, complementary and lysosomal activity, which led to an aggravation of chronic infectious processes. Conclusion. As a result of changes in the microelement composition of solid dental tissues, pathological erosion of solid dental tissues, pathological resorption of the roots of permanent teeth develops. In reducing the function of the thyroid gland, suppression of nonspecific protective factors such as bactericidal, complementary and lysosomal activity was observed. The latter leads to an aggravation of chronic infectious processes. These factors lead to early disability in patients with hypothyroidism and require the use of complex pathogenetically directed treatment and rehabilitation schemes.

Keywords: hypothyroidism, organism, functional changes

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1. Larin OS, Pankiv VI, Selivanenko MI, Hrachova OO. Analiz diyalnosti endokrynolohichnoi sluzhby Ukrainy u 2010 rotsi ta perspektyvy rozvytku medychnoi dopomohy khvorym z endokrynnoyu patolohiyeyu. Mizhnarodnyi endokrynolohichnyi zhurnal. 2011; 3(35): 10-8. [Ukrainian]
2. Belaya ZhE, Rozhinskaya LYa, Melnichenko GA. Sovremennye predstavleniya o deystvii tireoidnykh gormonov i tireotropnogo gormona na kostnuyu tkan. Problemy endokrinologii. 2006; 52(2): 48–54. [Russian]
3. Balabolkin MI, Klebanova EM, Kreminskaya VM. Fundamentalnaya i klinicheskaya tiroidologiya: rukovodstvo. M: Meditsina; 2007. 816 p. [Russian]
4. Vatseba TS. Vzayemozv’yazok mizh dyslipidemiyeyu ta insulinorezystentnistyu u khvorykh na pervynnyi hipotyreoz. Klinichna ta eksperymentalna patolohiya. 2013; 2(44): 42-6. [Ukrainian]
5. Kravchenko VI, Tkachuk LA, Vlasenko MV, ta in. Vyvchennya yodnoi zabezpechenosti zhinok ta ditey tsentralnoho rehionu Ukrainy. Endokrynolohiya. 2007; 12(2): 192–200. [Ukrainian]
6. Glazyrin DI. Osteoporoz i zabolevaniya shchitovidnoy zhelezy (nablyudeniya iz praktiki). Vestnik pervoy oblastnoy klinicheskoy bolnitsy. 2000; 4: 20–2. [Russian]
7. Grossman SS. Sostoyanie kostnoy tkani u bolnykh s zabolevaniyami shchitovidnoy zhelezy do i posle operativnogo lecheniya: Abstr. PhDr. (Med.). Vladivostok; 2002. 22 p. [Russian]
8. Endokrynolohiya. Ed by PM Bodnar. Vinnytsya: Nova knyha; 2010. 464 p. [Ukrainian]
9. Zakharova SM, Saveleva LV, Fadeeva MI. Ozhirenie i gipotireoz. Zdorov`ya Ukrayini. 2014; 8: 49-50. [Russian]
10. Zubkova ST, Buldygina YuV, Mikhaylenko EYu. Faktory serdechno-sosudistogo riska pri gipotireoze. Simeyna meditsina. 2011; 4: 31-6. [Russian]
11. Kikhtyak OP, Skripnik NV, Pasyechko NV. Zmini pokaznikiv vuglevodnogo i lipidnogo obminu u khvorikh iz sindromom gipotireozu. Visnik naukovikh doslidzhen. 2012; 2: 27-8. [Ukrainian]
12. Kravchenko VI. Medychni problemy yododefitsytu ta protydiya yod zalezhnym zakhvoryuvannyam. Endokrynolohiya. 2014; 19(4); 312. [Ukrainian]
13. Kravchun NA, Chernyavskaya YV. Hypotyreoz: epydemyolohyya, dyahnostyka, opyt lechenyya. Problemy endokrynnoy patolohyi. 2011; 3: 27-34. [Russian]
14. Tronko MD, Polumbryk MO, Kravchenko VI, Balon YaH. Naukovi aspekty vyrishennya problemy yododefitsytu u naselennya Ukrainy. Endokrynolohiya. 2011; 16(2): 189-99. [Ukrainian]
15. Popova EV, Anysymova TM, Nykytyna NM, Smolyahyn AY. Nekotorye osobennosty tyreoydnoho y ymmunnoho statusa u zdorovoho naselenyya y u lyts s patolohyey shchytovydnoy zhelezy. Ymmunolohyya Urala. Aktualnye voprosy fundamentalnoy y klynycheskoy allerholohyi y ymmunolohyi: V konferentsyya ymmunolohov Urala, 30 oktyabrya–1 noyabrya 2006 h: materyaly konf. M; 2006: 64–5. [Russian]
16. Oksyuta VM. Doslidzhennya stanu lipidnoho obminu v zhinok iz porushennyam reproduktyvnoi funktsiyi ta hipotyreozom. Bukovynskyi medychnyi visnyk. 2012; 4(16): 120-3. [Ukrainian]
17. Pankiv VI. Endemichnyi zob (yododefitsytni zakhvoryuvannya). Mizhnarodnyi endokrynolohichnyi zhurnal. 2012; 7: 127–34. [Ukrainian]
18. Pankiv VI. Syndrom hipotyreozu. Praktychna tyreoidolohiya. 2011; 3: 224. [Ukrainian]
19. Petrenko OD, Pysarenko YuM. Dosvid profilaktyky yododefitsytnykh zakhvoryuvan v endemichnomu rayoni Ukrainy. Problemy kharchuvannya. 2009; 3–4: 25–8. [Ukrainian]
20. Prystupyuk OM. Hipotyreoz: ushkodzhennya orhaniv ta system. Mizhnarodnyi endokrynolohichnyi zhurnal. 2011; 4: 104-9. [Ukrainian]
21. Fadeev VV, Melnychenko HA. Hypotyreoz: Rukovodstvo dlya vrachey. M: RKY Severo Press; 2014. 288 p. [Russian]
22. Khabrat BV, Lytvak OO, Hyryavenko OYa, Lysenko BM, Khabrat AV, Larina OV. Diahnostyka avtoimunnoho tyreoidytu u zhinok iz hinekolohichnymy zakhvoryuvannyamy. Klinichna endokrynolohiya ta endokrynna khirurhiya. 2013; 2: 56-8. [Ukrainian]
23. Shepelkevych AP, Zabarovskaya ZV. Problema osteoporoza pry zabolevanyyakh endokrynnoy systemy. Medytsynskye novosty. 2008; 7: 53–8. [Russian]
24. Kanaya AM, Harris F, Volpato S, Pérez-Stable EJ, Harris T, Bauer DC. Association between thyroid dysfunction and total cholesterol level in an older biracial population. The Health, Aging and Body Composition Study. Arch Intern Med. 2002; 162(7): 773–9. https://www.ncbi.nlm.nih.gov/pubmed/11926850. https://doi.org/10.1001/archinte.162.7.773
25. Dąbrowski MP, Dąbrowski MI, Stankiewicz W. The thymus in neuro-endocrine–immune network. Centr Eur J Immunol. 2011; 36(3): 188–92.
26. Hutchens S, Liu C, Jursa T, Shawlot W, Chaffee BK, Yin W, et al. Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice. J Biol.Chem. 2017 Jun 9; 292(23): 9760-73. https://www.ncbi.nlm.nih.gov/pubmed/28461334. https://www.ncbi.nlm.nih.gov/pmc/articles/5465498. https://doi.org/10.1074/jbc.M117.783605
27. Dhanwal DK. Thyroid disorders and bone mineral metabolism. Indian J Endocrinol Metab. 2011; 15(Suppl 2): S107–12. https://www.ncbi.nlm.nih.gov/pubmed/21966645. https://www.ncbi.nlm.nih.gov/pmc/articles/3169869. https://doi.org/10.4103/2230-8210.83339
28. Santana Lopes M, Jácome de Castro J, Marcelino M, Oliveira MJ, Carrilho F, Limbert E; Grupo de Estudos da Tiróide. [Iodine and thyroid: what a clinic should know]. Acta Med Port. 2012 May-Jun; 25(3): 174-8. https://www.ncbi.nlm.nih.gov/pubmed/23069238
29. Ianiro G, Mangiola F, Di Rienzo TA, Bibbò S, Franceschi F, Greco AV, et al. Levothyroxine absorption in health and disease, and new therapeutic perspectives. Eur Rev Med Pharmacol Sci. 2014; 18(4): 451-6. https://www.ncbi.nlm.nih.gov/pubmed/24610609
30. Diamanti-Kandarakis E, Dattilo M, Macut D, Duntas L, Gonos ES, Goulis DG, et al; COMBO ENDO TEAM.Mechanisms in endocrinology: Aging and anti-aging: a Combo-Endocrinology overview. Eur J Endocrinol. 2017 Jun; 176(6): R283-R308. https://www.ncbi.nlm.nih.gov/pubmed/28264815. https://doi.org/10.1530/EJE-16-1061
31. Voronych-Semchenko NM, Huranych TV. The changes of processes of free radical oxidation of lipids and proteins, antioxidant defence in rats with hypofunction of the thyroid gland in conditions of iodine and copper deficiency. Fiziol Zh. 2014; 60(4): 30-9. https://www.ncbi.nlm.nih.gov/pubmed/25335232. https://doi.org/10.15407/fz60.04.030
32. Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH. The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease. A metaanalysis. J Clin Endocrinol Metab. 2008; 93(8): 2998–3007. https://www.ncbi.nlm.nih.gov/pubmed/18505765. https://doi.org/10.1210/jc.2008-0167
33. McAninch EA, Miller BT, Ueta CB, Jo S, Kim BW. Thyroid Hormone at Near Physiologic Concentrations Acutely Increases Oxygen Consumption and Extracellular Acidification in LH86 Hepatoma Cells. Endocrinology. 2015 Nov; 156(11): 4325-35. https://www.ncbi.nlm.nih.gov/pubmed/26287403. https://doi.org/10.1210/en.2015-1221
34. Bassett JH, O’Shea PJ, Sriskantharajah S, Rabier B, Boyde A, Howell PG, et al. Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism. Mol Endocrinol. 2007; 21(5): 1095–107. https://www.ncbi.nlm.nih.gov/pubmed/17327419. https://doi.org/10.1210/me.2007-0033
35. Bernal J. Thyroid Hormones in Brain Development and Function. Endotext [digital resource]. 2015. (promoversion). Available from: https://www.ncbi.nlm.nih.gov/books/NBK285549
36. Garasto S, Montesanto A, Corsonello A, Lattanzio F, Fusco S, Passarino G, et al. Thyroid hormones in extreme longevity. Mech Ageing Dev. 2017 Jul; 165(Pt B): 98-106. https://www.ncbi.nlm.nih.gov/pubmed/28286215. https://doi.org/10.1016/j.mad.2017.03.002
37. Yeasmin S, Begum N, Begum S, Rahman SMH. Sensory Neuropathy in Hypothyroidism: Electrophysiological and Clinical Findingsю. J Bangladesh Soc Physiol. 2007; 2: 1–6. https://doi.org/10.3329/jbsp.v2i0.975