During the training, students are exposed to stress factors. In this case, physiological adaptation mechanisms are included. The purpose of this work was to study the biochemical parameters in the blood of students in preparation for exams. Determination of their possible biochemical manifestations of the influence of stress factors. We researched almost healthy students and examined their common biochemical parameters. They characterized the functional state of individual organs and systems. Material and methods. We studied the content of products of free radical oxidation of proteins, lipids, the activity of paraoxonase, catalase, superoxide dismutase, myeloperoxidase, and indicators of the activity of systemic inflammation. Results and discussion. These studies showed that biochemical indicators of individual organs and systems functioning did not go beyond the reference values. The metabolic rate of students did not differ from the reference values. The subjects showed a significant decrease in the activity of paraoxonase-1, which determines the antioxidant, anti-inflammatory, antithrombotic and anti-atherogenic properties of high density lipoproteins. There was also an increased content of free radical lipid peroxidation products. They acted as biomarkers of damage. By their content, one can evaluate the intensity of the course of free radical processes. This indicates the formation of intoxication syndrome, an increase in the atherogenic potential of the blood. The activity of the enzyme link of the antioxidant defense system was reduced. A pronounced activation of the processes of free radical oxidation of protein molecules was observed. In this case, protein peroxidation was the trigger of pathological processes. It is also the earliest indicator of oxidative stress. The established changes reflected the general reaction of the body of the subjects. They indicated the formation of oxidative stress which involved lipid and protein components. The antioxidant defense mechanism was inhibited, aimed at reducing the level of reactive oxygen species and products of free radical oxidation of macromolecules. Conclusion. The results of the study indicated the presence of signs of oxidative stress in the body of students in preparation for exams. These changes indicated the formation of intoxication syndrome. Atherogenic potential of blood increased. The initiation and progression of atherogenic damage to various vascular pools in the body was possible. Thus, these students can be attributed to the risk group for the occurrence of vascular pathology.
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