Low grade inflammation (LGI) is recognized as a basic factor in many internal diseases, including atherosclerosis, diabetes, type 2, many forms of cancer, COPD and Alzheimer's disease. In the etiology of SV leading role belongs to various forms of stress, the Western type diet, hypodinamie, infections and endotoxins. Regular physical exercise of moderate intensity can reduce the risk of developing diseases associated with SV by reducing visceral fat mass, decrease production of inflammatory cytokines and increase anti-inflammatory of myokines. It was found that the major chronic diseases of humanity: atherosclerosis, type 2 diabetes 4, many forms of cancer, chronic obstructive pulmonary disease, Alzheimer's disease and others associated with chronic systemic inflammation of low intensity (NE). NE is different from acute local inflammation relatively small increase in the level of circulating cytokines (2-4 times) and a persistent course. Currently installed many molecular mechanisms of implementation of HR in particular pathological processes. In these studies the use of pharmacological agents based prevention and treatment of diseases associated with the NE. One of the important achievements is the understanding of the role of muscle tissue, lack of activity, which is one of the main reasons for CB and physical training - the most important and promising method for preventing these diseases. Physical activity is a means of treatment of coronary heart disease, chronic heart failure, type 2 diabetes and COPD. There are a large number of studies show a decrease in HR during physical exercise. Body mass index and smoking, are important factors. In the Greek study, ATTICA, it was found that circulating levels of proinflammatory cytokines was reduced by persons engaged in physical exercise, compared with sedentary, including healthy young adults. Elucidation of the mechanism of participation in the reduction of muscle tissue CB met with paradox significant secretion of IL-6 working muscles. There is an assumption that this phenomenon is related to the need to replenish stocks of glucose, glycogen and free fatty acids working muscles Elucidation of the mechanism of participation in the reduction of muscle tissue LGI met with paradox significant secretion of IL-6 working muscles. There is an assumption that this phenomenon is related to the need to replenish stocks of glucose, glycogen and free fatty acids working muscles. AMPA is a metabolic sensor activated by a change in energy status of the cell. In contrast to the pro-inflammatory effect of IL-6, generated activated macrophages with IL-1 and TNF-a during physical training IL-6 myocytes generated with IL-1 antagonist and anti-IL-10. Increased levels of cortisol and anti-TNF-alpha factor during exercise also provides an anti-inflammatory effect of 30 minutes of moderate-intensity exercise can induce anti-inflammatory activity of muscle and adipose tissue. Physical activity reduces the level of systemic inflammation by decreasing visceral fat, and cytokines produced by them adipokines inflammation. Working skeletal muscle is an endocrine organ, producing miokines, has anti-inflammatory effect, reduces IR and actions as preventively and medical factor in the NE, TS and associated disorders. Moderate physical activity for 30 minutes a day, can significantly affect the level of NE and the development of chronic internal diseases.
Keywords: physical activity, systemic inflammation, internal diseases
Full text: PDF (Rus) 102K