The purpose of the study was the experimental study of the progressing morphological peculiarities of the blood microcirculatory bed of the tongue back mucosa of the albino rats who consumed food additives (monosodium glutamate, sodium nitrite, Ponceau 4R), supplemented to their ration, during 4 weeks. Materials and methods. The experiment involved 30 outbred albino rats of both gender, weighted 204±0.67 g. All studies were conducted in accordance with the norms of bioethics and ethical principles of work with experimental animals. Experimental animals consumed the combination of food additives, namely, monosodium glutamate, Ponceau 4R and sodium nitrate, supplemented to their ration, during 1 and 4 weeks. Conventional paraffin and semi-thin sections were made from the tongue preparations and studied using the light microscope. Results and discussion. It has been established that the consumption of the complex of food additives, supplemented to the daily ration of the laboratory animals during 1 week caused a desolation of arterioles and plethora of veins in the lamina propria of the mucous membrane of the back of the tongue. The phenomena of increased hydration of the interstitium were quite often observed in the perivascular spaces. Following the 4 weeks of the consumption of the supplemented food additives all sections of the blood microcirculatory bed showed the phenomena of anemia. Swelling of the endothelial cells was often observed in both arterioles and exchange microvessels. Conducting morphometric studies indicates the deepening of the processes that took place in the previous experimental group. Thus, in the studied parts of the mucous membrane of the back of the tongue the increase of the density of blood microvessels continued. The diameter of blood microvessels in all studied sections of the mucous membrane of the back of the tongue increased slightly. This is the first article which investigates the morphometric parameters of the blood microcirculatory tract structure of the tongue mucous membrane under the combined effects of food additives. Conclusion. The findings of the morphometric studies show that consumption of the complex of food additives, supplemented to the ration, leads to an increase in the number of blood vessels in all parts of the mucous membrane of the tongue and a slight enlargement of the diameter of all sections of the blood microcirculatory bed. The described changes are progressive and become more obvious by the end of the experimental period
Keywords: tongue, mucous membrane, blood microcirculatory bed, food additives
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