ISSN 2415-3060 (print), ISSN 2522-4972 (online)
  • 33 of 44
УЖМБС 2022, 7(2): 231–241

Approaches to Determination of Mechanisms of Ergogenic Action of Non-Pharmacological Antioxidant Orientations

Gunina L. M. 1, Belenichev I. F. 2, Danylchenko S. I. 3, Kozlova O. K. 1

One of the powerful methodologies of ergogenic nature is the use of vibration loads in the mode of "whole body vibration", which in terms of frequency of oscillations mostly coincides with the frequency of oscillations of the microstructures of the body itself. The purpose of the study was to evaluate the effectiveness of the use of non-pharmacological agents with antioxidant nature of action in vibration loads in athletes. Materials and methods. To assess the effectiveness of vibration loads as a non-pharmacological ergogenic agent, we have chosen vibration loads as one of the most characteristic mechanical effects on the human body. The study of the effectiveness and impact mechanisms of vibration loads on the body of athletes using domestic spiral-vortex simulator involved 24 representatives of cyclic sports. They are qualified rowers in kayaks and canoes. These athletes were divided into equal groups (12 people) by the number of group members – control and main. In the dynamics of research, not only changes under the influence of additional vibration loads of indicators of special physical performance were evaluated, but also numerous homeostatic parameters that reflect the severity of oxidative stress, structural and functional state of cell membranes, the degree of endogenous toxicity, intensity of humoral immunity, and also systemic factors that affect the formation of physical performance – the activity of the factor induced by hypoxia and the main angiogenic factor. Vibration load after the main standard training session was created using a spiral-vortex simulator «PLH-9051» for 30 minutes. The examination of the participants was conducted before starting and at the end of the stage of direct preparation for the competition. Results and discussion. The results of our study have proven that the vibration of the whole body in this mode does not lead to negative changes in the basic standard laboratory parameters of the body. At the same time, it was found that the indicators in the 12-minute test (endurance characteristics) and in the one-minute test (speed characteristics) significantly improved. As for the metabolic changes that are the basis for such rearrangements of the parameters of special physical performance, it is established that there is no additional activation of oxidative stress during vibration training. Vibration loads, firstly, have a positive effect at the subcellular level – the activity of lipid peroxidation reduces and antioxidant protection improves. At the same time, positive changes occur in the activation links of angiogenetic characteristics, which are an indirect reflection of the increase in the number of microvessels and the improvement of tissue blood circulation with the increase of oxygen transfer and plastic and energy substrates. Conclusion. Thus, according to the obtained data, vibration loads in the mode of vibration load of the whole body lasting 30 minutes after standard training load are similar to hypoxic training conditions, but without the occurrence of oxidative stress, and can be used for the same purpose – to improve adaptation mechanisms and increase physical performance at the special preparatory stage of athletes specializing in cyclic sports, and in a more general interpretation – in sports with a predominantly aerobic mechanism of energy supply

Keywords: sport, physical performance, vibration loads, metabolic changes, oxidative stress, hypoxia, angiogenesis

Full text: PDF (Ukr) 466K

  1. Platonov VN, Oleynyk SA, Gunyna LM. Dopyng v sporte y problemy farmakologycheskogo obespechenyya podgotovky sportsmenov [Doping in sports and the problems of pharmacological support for the training of athletes]. M: Sovetskyy sport; 2010. 306 s. [Russian]
  2. Bean A. Sports supplements. What nutritional supplements really work? London: A&C Black; 2007. 120 p.
  3. Sukhorukov VS. K razrabotke ratsyonalnykh osnov energotropnoy terapii [To the development of rational foundations of energy-tropic therapy]. Ratsyonalnaya farmakoterapyya. 2007;(2):40–7. [Russian]
  4. West DWD, Abou Sawan S, Mazzulla M, Williamson E, Moore DR. Whey Protein Supplementation Enhances Whole Body Protein Metabolism and Performance Recovery after Resistance Exercise: A Double-Blind Crossover Study. Nutrients. 2017;9(7):735. PMID: 28696380. PMCID: PMC5537849.
  5. Makarova GA, Polyaev BA. Mediko-biologicheskoe obespechenie sporta za rubezhom [Medical and biological support of sports abroad]. M: Sovetskyy sport; 2012. 309 s. [Russian]
  6. Ramana KV, Srivastava S, Singhal SS. Lipid Peroxidation Products in Human Health and Disease 2019. Oxid Med Cell Longev. 2019;2019:7147235. PMID: 31885812. PMCID: PMC6900947.
  7. Silva D, Arend E, Rocha SM, Rudnitskaya A, Delgado L, Moreira A, et al. The impact of exercise training on the lipid peroxidation metabolomic profile and respiratory infection risk in older adults. Eur J Sport Sci. 2019;19(3):384−93. PMID: 30035670.
  8. Mirzoev O.M. Vosstanovitelnye sredstva v sisteme podgotovki sportsmenov [Restorative means in the system of training athletes]. M: Fizkultura i sport; 2005. 220 s. [Russian]
  9. Vinogradov VE, Mishchenko VS. Effektivnost vzaimosvyazannogo ispolzovaniya sredstv vosstanovleniya i stimulyatsii rabotosposobnosti v mikrotsiklakh s bolshimi nagruzkami spetsialnoy napravlennosti (na primere akademicheskoy grebli) [The effectiveness of the interconnected use of means of recovery and stimulation of working capacity in microcycles with high loads of a special direction (on the example of academic rowing)]. Fizicheskoe vospitanie studentov. 2011;(3):16-22. [Russian]
  10. Fatouros IG, Chatzinikolaou A, Douroudos II, Nikolaidis MG, Kyparos A, Margonis K, et al. Time-course of changes in oxidative stress and antioxidant status responses following a soccer game. J Strength Cond Res. 2010;24(12):3278−86. PMID: 19996787.
  11. Mikheev AA. Teoriya i metodika vibratsionnoy trenirovki v sporte (biologicheskoe i pedagogicheskoe obosnovanie dozirovannogo vibrotreninga) [Theory and methodology of vibration training in sports (biological and pedagogical substantiation of dosed vibration training)]. M: Sovetskiy sport; 2011. 615 s. [Russian]
  12. Osipov VP, Lukyanova EM, Antipkin YuG. Metodika statisticheskoy obrabotki meditsinskoy informatsii v nauchnykh issledovaniyakh [Technique of statistical processing of medical information in scientific research]. Pod red VP Osipova. K: Planeta lyudey; 2002. 200 s. [Russian]
  13. Costa AD, Garlid KD. MitoKATP activity in healthy and ischemic hearts. J Bioenerg Biomembr. 2009;41(2):123-6. PMID: 19353252.
  14. Olszewska AM, Sieradzan AK, Bednarczyk P, Szewczyk A, Żmijewski MA. Mitochondrial potassium channels: A novel calcitriol target. Cell Mol Biol Lett. 2022;27(1):3. PMID: 34979905. PMCID: PMC8903690.
  15. Chua YL, Dufour E, Dassa EP. Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production. J Biol Chem. 2010;285(41):31277-84. PMID: 20675386. PMCID: PMC2951202.
  16. Saldana-Caboverde A, Nissanka N, Garcia S, Lombès A, Diaz F. Hypoxia Promotes Mitochondrial Complex I Abundance via HIF-1α in Complex III and Complex IV Eficient Cells. Cells. 2020;9(10):2197. PMID: 33003371. PMCID: PMC7599499.
  17. Aalling N, Hageman I, Miskowiak K, Orlowski D, Wegener G, Wortwein G. Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats. J Neurosci Res. 2018;96(1):103−6. PMID: 28752903.
  18. Wagatsuma A. Effect of aging on expression of angiogenesis-related factors in mouse skeletal muscle. Exp Gerontol. 2006;41(1):49-54. PMID: 16289925.
  19. Viscor G, Torrella JR, Corral L, Ricart A, Javierre C, Pages T, et al. Physiological and Biological Responses to Short-Term Intermittent Hypobaric Hypoxia Exposure: From Sports and Mountain Medicine to New Biomedical Applications. Front Physiol. 2018;9:814. PMID: 30038574. PMCID: PMC6046402.
  20. Moghetti P, Bacchi E, Brangani C, Donà S, Negri C. Metabolic Effects of Exercise. Front Horm Res. 2016;47:44−57. PMID: 27348753.
  21. Bodine SC. Hibernation: the search for treatments to prevent disuse-induced skeletal muscle atrophy. Exp Neurol. 2013;248:129−35. PMID: 23769906.