ISSN 2415-3060 (print), ISSN 2522-4972 (online)
  • 19 of 33
УЖМБС 2021, 6(4): 134–141

Clinical and Laboratory Substantiation of Improvement of the Treatment Method of Boils and Carbuncles of Maxillofacial Area

Kovpak L. V., Leschuk Ye. S., Leschuk S. Ye., Maslyuk M. V., Martynets M. Ya., Ruzhytska O. V.

Selection of medications to apply locally for treatment of abscessive forms of boils and carbuncles of maxillofacial area still remains a debatable issue, despite their wide range. Alternative means for application use in surgical interventions in maxillofacial area are medications of natural origin. Drugs of natural origin that have anesthetic and anti-inflammatory properties include cayenne pepper fruits (Capsicum annuum). Therapeutic properties are caused by the presence in their structure of the main active ingredient – capsaicin alkaloid and other biologically active compounds (vitamins, flavonoids, minerals, etc.) which influence the main pathogenetic inflammation bonds. Capsaicin has a distinct keratoplastic effect and normalizes microcirculation in the tissues. Phytogel with anti-inflammatory and anesthetic action (patent for utility model No. 30032 “Phytogel with anti-inflammatory and anesthetic action”) was developed for clinical use based on phytosubstance of pepper cayenne fruits (patent for utility model No. 19547 “Method of obtaining phytosubstance with anti-inflammatory action”). The purpose of the study was to increase treatment efficiency of boils and carbuncles of maxillofacial area by using a medication based on the capsicum annuum fruits. Materials and methods. The analysis of inspection and treatment results of 45 patients having boils and carbuncles of maxillofacial area at abscessing stage is carried out. On the first, third, seventh and tenth day of treatment, a number of clinical indicators (presence and intensity of edema and infiltrate, condition of regional lymph nodes, presence and intensity of pain in the inflammation site, time of wound exudate clearance, intensity of regeneration, length of hospital stay treatment) and indicators obtained by laboratory methods (total number of leukocytes, leukocyte intoxication index, erythrocyte sedimentation rate) were studied and compared with the same parameters in the control group, where traditional treatment was carried out; and when using the comparison medication - 3% propolis ointment. Results and discussion. Analysis of the results showed that despite the similarity of the clinical picture and laboratory parameters on admission to the hospital, the healing of purulent wounds under the influence of capsicum annuum phytogel was more effective comparing with traditional methods of surgical treatment. Thus, wound epithelialization of patients in the experimental group No. 1 was observed on average on the seventh day, which was significantly faster than in other experimental groups. Sanation of the inflammatory focus also decreased body intoxication, which can be traced by the dynamics of changes in the degree of leukocytosis, leukocyte intoxication index, erythrocyte sedimentation rate. On the tenth day, the clinical blood parameters of patients of the experimental group No. 1 were close to the average norm. As a result, the length of stay in hospital was significantly reduced. The average bed-day for the experimental group No. 1 was 7.5 days, which is authentically less than for patients of the control and experimental group No. 2. Conclusion. According to the results of clinical and laboratory studies, the efficiency of the proposed method has been proved in comparison with traditional treatment of boils and carbuncles of maxillofacial area

Keywords: boils and carbuncles of maxillofacial area, phytogel of capsicum annuum fruits, surgical treatment, anti-inflammatory action

Full text: PDF (Ukr) 291K

  1. Tymofyeyev OO. Shchelepno-lytseva khirurhiya [Maxillofacial surgery]. K: Medytsyna; 2017. 752 s. [Ukrainian]
  2. Matolych UD, Ushtan SV, Petrov DB. Osoblyvosti zapalnykh zakhvoryuvan shchelepno-lytsevoi dilyanky [Features of inflammatory diseases of the maxillofacial area]. Visnyk problem biolohiyi i medytsyny. 2019; 2(2): 241-243. [Ukrainian]
  3. Batrakov AV. Furunkuly litsa. Chast I [Furunculas faces. Part I]. Uchebnoe posobie. SPb: Chelovek; 2017. 45 s. [Russian]
  4. Batrakov AV. Furunkuly litsa. Chast II [Furunculas faces. Part II]. Uchebnoe posobie. SPb: Chelovek; 2018. 40 s. [Russian]
  5. Patent 30032 Ukraine, MPK A61K 9/06 (2006.01), A61P 23/00. Fitohel z protyzapalnoyu ta znechulyuyuchoyu diyeyu / Dubrovna LV, Fedin RM, Benzel LV, Vovk YuV, Benzel IL. (UA); zayavnik i vlasnik patentu Danylo Halytskyi Lviv National University (UA). № u200710519; zayavl 24.09.07 ; opubl 11.02.08. Byul № 3. [Ukrainian]
  6. Villa-Rivera MG, Ochoa-Alejo N. Chili Pepper Carotenoids: Nutraceutical Properties and Mechanisms of Action. Molecules. 2020 Nov 27; 25(23): 5573.
  7. Pavlenko OV, Bida RYu. Kryteriyi otsinky endohennoi intoksykatsiyi za danymy intehralnykh hematolohichnykh indeksiv u patsiyentiv z hostrymy hniynymy odontohennymy zapalnymy protsesamy u rizni likuvalni terminy [Criteria for evaluating endogenous intoxication according to integrated hematological indices in patients with acute purulent odontogenic inflammatory processes in various therapeutic terms]. Visnyk problem biolohiyi i medytsyny. 2016; 4(134): 258-264. [Ukrainian]
  8. Tymofeev AA, Blynova VP, Umyrov AV, Myroshnyk AA, Ukharskaya OA, Dubychenko SI, ta in. Imunokorehuyucha terapiya khvorykh iz hniyno-zapalnymy zakhvoryuvannyamy m'yakykh tkanyn shchelepno-lytsevoi dilyanky ta shyi [Immunocorrective therapy of patients with purulent-inflammatory diseases of soft tissues of the maxillofacial area and neck]. Suchasna stomatolohiya. 2019; 2(96): 80-86. [Ukrainian]
  9. Tymofeev AA, Umyrov AV, Myroshnyk AA, Dubychenko SY. Likuvannya hniynykh ran u khvorykh na flehmony shchelepno-lytsevoi dilyanky ta shyi [Treatment of purulent wounds in patients with phlegmons of the maxillofacial area and neck]. Suchasna stomatolohiya. 2019; 2(96): 66-72. [Ukrainian]
  10. Hernández-Pérez T, Gómez-García MDR, Valverde ME, Paredes-López O. Capsicum annuum (hot pepper): An ancient Latin-American crop with outstanding bioactive compounds and nutraceutical potential. A review. Compr Rev Food Sci Food Saf. 2020 Nov; 19(6): 2972-2993.