ISSN 2415-3060 (print), ISSN 2522-4972 (online)
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УЖМБС 2020, 5(6): 129–135
https://doi.org/10.26693/jmbs05.06.129
Clinical Medicine

The Role of Shear Wave Ultrasound Elastography in the Diagnosis of Adenomyosis and / or Hyperplastic Processes of the Endometrium

Lazurenko V. V., Melikhova T. V.
Abstract

Today, hysteroscopy, ultrasound and magnetic resonance imaging are most often used in clinical practice for the diagnosis of adenomyosis. However, the high frequency of diagnostic errors (from 20 to 40%), depending on the experience of the operator and equipment, detailing the structure of the myometrium and the parameters of ultrasound differentiation of adenomyosis, requires the search for new optimal diagnostic methods. The purpose of our study was to determine the parameters of ultrasound elastography of the shear wave in patients with adenomyosis and / or hyperplastic processes of the endometrium. Material and methods. The study included 128 patients aged from 27 to 53 years (mean 39.4 ± 8.6). The first group included 38 (29.6%) patients diagnosed with grade I-II adenomyosis, the second group had 41 (32.1%) patients with a combination of grade I-II adenomyosis with endometrial hyperplastic processes and / or uterine leiomyoma, the third group consisted of 39 (30.5%) women only with hyperplastic processes of the endometrium. The control fourth group included 10 (7.8%) women without endometrial pathology, who sought women's advice on primary infertility. Results and discussion. When performing shear wave elastography, significant differences in the color of myometrial mapping were found between patients of the first, third and control groups (p <0.001). Unchanged myometrium in all patients of the control group was represented by shades of blue, and the staining was uniform in 9 (90%) subjects. In patients of the first group, the myometrium was stained with shades of red in 31 (81.63%) cases and shades of yellow in 3 (7.8%) cases; in 23 (60.5%) cases there was inhomogeneous red staining and in 14 (36.8%) cases staining was inhomogeneous in shades of red-yellow-light blue. When performing elastography in patients of the second group in the projection of the myoma was more often detected staining in shades of red in 20 (48.8%) cases, yellow in 6 (14.6%) and light blue in 3 (7.3%) cases; in 28 (68.3%) cases there was inhomogeneous red staining and in 19 (46.3%) cases staining was inhomogeneous in shades of red-yellow-light blue. In the third group in the projection of the leiomatous node was more often determined by staining in shades of red in 22 (56.4%) cases, yellow in 8 (20.5%) and light blue in 6 (15.4%) cases, colors on the background of the blue myometrium; inhomogeneous staining of myomatous nodes was detected in 31 (79.5%), and homogeneous staining was in 7 (17.9%) cases. Unchanged myometrium in the control group was characterized by significantly lower values of the Young's modulus 25.2 (17.9-34.1 kPa), while in the group of adenomyosis the average value of Emean reached 71.8 (17.9-281.3 kPa), was maximally high and significantly different from the indicators of the control group and from the indicators of group 3 patients 29.6 (13.5-58.9 kPa). The rates of patients of the second group, in whom grade I-II adenomyosis was combined with endometrial hyperplastic processes and / or uterine leiomyoma 54.7 (15.6-133.9 kPa) were also significantly higher than the values of the control group and the third group. Conclusion. Shear wave ultrasound is a minimally invasive and accessible method of high-quality preoperative diagnosis, necessary to avoid hysterectomy and clarify the diagnosis without surgery, which is recommended for use in practice to improve the accuracy of diagnosis of adenomyosis

Keywords: ultrasonic elastography of shear wave, adenomyosis, endometriosis, endometrial hyperplastic processes

Full text: PDF (Ukr) 359K

References
  1. Shklyar AA, Adamyan LV, Kogan EA, Paramonova NB, Kozachenko IF, Gavrilova TYu, et al. Trudnosti diagnostiki uzlovoy i diffuznoy form adenomioza [Difficulties in diagnosing nodular and diffuse forms of adenomyosis.] Akusherstvo i ginekologiya. 2015; 3: 67-72. [Russian]
  2. Dzhamalutdinova KM, Kozachenko IF, Gus AI, Adamyan LV. Sovremennyye aspekty patogeneza i diagnostiki adenomioza [Modern aspects of the pathogenesis and diagnosis of adenomyosis]. Akusherstvo i ginekologiya. 2018; 1: 29-34. doi:10.18565/aig.2018.1.29-34
  3. Guerriero S, Ajossa S, Orozco R, Perniciano M, Jurado M, Melis GB, et al. Diagnostic accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in the recto-sigmoid: a meta-analysis. Ultrasound Obstet. Gynecol. 2016; 47(3): 281-9. https://doi.org/10.1002/uog.15662
  4. Saiddanesh ShF, Chuprynin VD, Khilkevich EG, Buralkina NA, Pavlovich SV, Danilov AYu, et al. Sovremennyye metody diagnostiki rasprostranennykh form endometrioza [Modern diagnostic methods for common forms of endometriosis] Akusherstvo i ginekologiya. 2017; 5: 39-43. [Russian]
  5. Kurjak A, Chervenak FA. Donald school textbook of ultrasound in obstetrics and gynecology. The Health Sciences Publisher; 2017. 1111 p.
  6. Kogan EA, Paramonova NB, Shklyar AA, Fayzullina NM, Adamyan LV. Kliniko-morfologicheskiye osobennosti ochagovoy, uzlovoy i diffuznoy form adenomioza [Clinical and morphological features of focal. nodular and diffuse forms of adenomyosis]. Arkhiv akusherstva i ginekologii im VF Snegireva. 2016; 3(1): 18-22. [Russian]
  7. Stoelinga B, Hehenkamp WJK, Brolmann HAM, Huirne JAF. Real-time elastography for assessment of uterine disorders. Ultrasound Obstet. Gynecol. 2014; 43(2): 218-26. https://doi.org/10.1002/uog.12519
  8. Zhang M, Wasnik AP, Masch WR, Rubin JM, Carlos RC, Quint EH, et al. Transvaginal ultrasound shear wave elastography for the evaluation of benign uterine pathologies: A prospective pilot study. J Ultrasound Med. 2019; 38(1): 149-55. https://doi.org/10.1002/jum.14676
  9. Diomidova VN, Zakharova OV, Petrova OV. Elastografiya sdvigovoy volnoy v otsenke endometriya i miometriya u zdorovykh zhenshchin reproduktivnogo vozrasta [Shear wave elastography in the assessment of endometrium and myometrium in healthy women of reproductive age]. Ultrazvukovaya i funktsionalnaya diagnostika. 2015; 5: 51-6. [Russian]
  10. Manchanda S, Vora Z, Sharma R, Hari S, Das CJ, Kumar S, et al. Quantitative sonoelastographic assessment of the normal uterus using shear wave elastography: An initial experience. J Ultrasound Med. 2019; 38(12): 3183-9. https://doi.org/10.1002/jum.15019
  11. Mitkov VV, Khuako SA, Tsyganov SE, Kirillova TA, Mitkova MD. Sravnitelnyy analiz dannykh elastografii sdvigovoy volnoy i rezultatov morfologicheskogo issledovaniya tela matki (predvaritelnyye rezultaty) [Comparative analysis of shear wave elastography data and the results of morphological examination of the uterine body (preliminary results)]. Ultrazvukovaya i funktsionalnaya diagnostika. 2013; 5: 99-114. [Russian]