The purpose of the study was to compare the indicators of connective tissue metabolism in patients with mitral valve prolapse, type 1 diabetes mellitus, and patients with a combination of these pathologies. Material and methods. To study the processes of connective tissue metabolism, we determined the level of free and bound hydroxyproline, as well as the content of sulfatedglycosaminoglycans in the blood serum of patients with mitral valve prolapse, type 1 diabetes mellitus and a combination of these pathologies were determined. The ratio of free and peptide-bound hydr was calculated. Results and discussion. We found violations of the balance of destructive and synthetic processes in the extracellular matrix of connective tissue. They were characterized by an increase in the content of hydroxyproline fractions and sulphated glycosaminoglycans in the blood serum of patients of all groups. The robtained results showed that patients with comorbid pathology had the highest activation of collagen metabolism, as evidenced by high levels of free and peptide-bound hydroxyproline relative to the norm and the values of these indicators in patients with isolated pathology, as well as an increase in the proportion of peptide-bound hydroxyproline. Changes in the content of sulphated glycosaminoglycans in patients with combined pathology were less characteristic, the overall level of their content did not differ from the control. At the same time, the highest values among the fractions of sulfated glycosaminoglycans were found in the group of patients with type 1 diabetes (II fraction – medium-soluble compounds: chondroitin-4-sulfate, dermatan-sulfate). Consequently, in patients with mitral valve prolapse, type 1 diabetes mellitus and a combination of these pathologies changed the functional state of connective tissue, which were manifested by changes in the direction and rate of exchange of collagen and proteoglycans of the extracellular substance of connective tissue. Conclusion. We revealed revealed the imbalance of the destructive and synthetic processes in the extracellular matrix of connective tissue in patients with comorbidity (diabetes mellitus type 1 + mitral valve prolapse). It was manifested by increased blood content of the fractions of free and peptidoglycan hydroxyproline, the changing balance of free and peptidoglycan hydroxyproline an increase in the proportion peptidoglikanov, as well as increased content of sulphated glycosaminoglycans II and III fractions.

Keywords: mitral valve prolapse, type 1 diabetes mellitus, undifferentiated connective tissue dysplasia, hydroxyproline, glycosaminoglycansulfates

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