ISSN 2415-3060 (print), ISSN 2522-4972 (online)
  • 37 of 60
УЖМБС 2019, 4(6): 255–259

Evaluation of Clinical Efficacy of Using Aprotinin Fluctuophoresis after Dental Surgery

Paterega N., Ogonovsky R.

Methods for prevention and treatment of local inflammatory complications after surgery in the distal segment of the mandible were developed. The purpose of the study was to evaluate the clinical efficacy of the combined use of aprotinin and fluctuating current in the treatment of acute inflammatory response caused by surgery in the distal segment of mandible. Material and methods. Surgical treatment of 30 patients aged 16-28 years for lower third molars retention was performed. Patients of the main group during the first 3 days after impacted lower third molars surgery were performed on the site of lesions of the external oral fluctuophoresis of aprotinin. A device of low-frequency electrotherapy "Radius - 01" (Belarus) and a drug on the basis of aprotinin called "Kontriven", Biopharma, PrAT, Kyiv were used. Results and discussion.The results of the study showed that the combined use of aprotinin and fluctuating current in the form of fluctuophoresis contributed to a faster reduction of the manifestations of acute inflammatory reaction, which was clinically manifested by a statistically significant decrease in the intensity of pain, soft tissue swelling, the inflammatory contracture and local temperature. On the third day pain scores decreased in the main group by 41.3 %, against 34.0% in the comparison group (p<0.05). The increase in soft tissue of edema on the lesion side was 18.7 % lower in the main group than in the comparison group (p<0.01). The rate of inflammatory contracture in the patients of the main group decreased by 40.3%, against 17.9 % (p<0.01) in the comparison group. Cheek thickening on the 5th day decreased by 69 % in the main group and by 31 % in the comparison group (р<0.01). Local thermometry analysis revealed a statistically significant difference between the clinical groups (p<0.01), starting from the 3rd postoperative day. Conclusions. Fluctuating current has an anti-inflammatory effect, and when combined with its medication increases this positive effect. The use of aprotinin, which has anti-quinine properties, reduces inflammation, swelling and pain, improves microcirculation and healing of postoperative wounds, is advisable after surgery. The developed and tested treatment method promotes faster elimination in the early postoperative period of clinical manifestations of acute inflammatory reaction (pain, soft tissue swelling, trismus, local hyperthermia), is affordable and effective and can be used in the practice of dental surgeons.

Keywords: fluctuophoresis, aprotinin, lower molars

Full text: PDF (Ukr) 197K

  1. Aravena PC, Astudillo P, Miranda H, Manterola C. Reliability and validity of measuring scale for postoperative complications in third molar surgery. BMC Oral Health. 2018; 18(1): 25.
  2. Hohol AM, Pankevych AI, Kolisnyk IA. Vybir metodu atypovoho vydalennia tretikh nyzhnikh moliariv u zalezhnosti vid yikh polozhennia v aspekti profilaktyky pisliaoperatsiinykh sensornykh porushen [Vibration to the method of atypical visualization of the third lower molars in the fallow area and the position in the aspect of the prevention of sensory sensor damage]. Visnyk problem biolohii i medytsyny. 2016; 1(128): 179-83. [Ukrainian]
  3. Jawdekar AS, Vora M, Govalkar P, Pawar K. Сlinical evaluation of efficacy of proteolytic enzymes: trypsin and chymotrypsin on post-operative sequelae following the extraction of impacted mandibular third molars. Global Journal for research analysis. 2017; 6: 71-3.
  4. Khomych NM. Kompleksne mistseve likuvannia pisliaoperatsiinykh uskladnen atypovoho vydalennia nyzhnikh tretikh moliariv [Complex topical treatment of postoperative complications of atypical removal of the lower third molars]. Lviv: LNMU im Danyla Halytskoho; 2017. 20 s. [Ukrainian]
  5. Paterega NI, Shamlian OV, Shevchuk LP. Eksperymentalne vyvchennia protyzapalnoho efektu aprotyninu ta fliukturuiuchykh strumiv [Experimental study of the anti-inflammatory effect of aprotinin and fluctuating currents]. Visnyk problem biolohii i medytsyny. 2017; 3(141): 195-8. [Ukrainian]
  6. Jegadeesan VV, Ponnaiyan D. Impact of Aprotinin - A Proteolytic Enzyme on Postsurgical Symptoms in Patients Undergoing Third MolarSurgeries. J Clin Diagn Res. 2016; 10(1): 18–22.
  7. Yakovenko NP, Samoilenko VB. Fizioterapiia [Physiotherapy]. Pidruchnyk dlia med VNZ I—III ra 2-he vyd, vypr. Zatverdzheno MOZ. Kyiv: VSV «Medytsyna»; 2018. 256 s. [Ukrainian]
  8. Malyshev NA, Zhyrnov OP, Poiarkov SV. Antyvyrusnye y protyvovospalytelnye mysheny aprotynyna: perspektyvy novoho yspolzovanyia. Pulmonolohyia. 2009; 3: 109–18.
  9. Huskisson EC. Measurement of pain. Lancet.1974 Nov 9; 2(7889): 1127-31. Https:// Https://
  10. Patent 104391 Ukraine. Sposib dynamichnoi otsinky pisliaoperatsiinoho nabriaku miakykh tkanyn u diliantsi shchoky i kuta nyzhnoi shchelepy [Method for the dynamic evaluation of postoperative soft tissue edema in the area of the cheek and lower jaw] / Paterega NI, Ohonovskyi RZ, Mokryk OIa, Vynarchuk-Patereha VV, Sorokivskyi IS, (UA); zayavnik i vlasnik patentu Lvivskyi natsionalnyi medychnyi universytet imeni Danyla Halytskoho (UA). zayavl 25.01.2016. [Ukrainian]
  11. Patent 104390 Ukraine. Instrument dlia vymiriuvannia tovshchyny shchoky [Cheek thickness measuring tool] / Paterega NI, Mokryk OIa, Ohonovskyi RZ, Voloshkevych PP, (UA); zayavnik i vlasnik patentu Lvivskyi natsionalnyi medychnyi universytet imeni Danyla Halytskoho (UA). zayavl 25.01.2016. [Ukrainian]
  12. Jovanović G, Burić N, Kesić L. Effect of low power laser on postoperative trismus. FACTA UNIVERSITATIS, Series: Medicine and Biology. 2004; 11(3): 136–8.
  13. Arakeri G, Rai KK, Shivakumar HR, Jayade B. A randomized clinical trial to compare the efficacy of submucosal aprotinin injection and intravenous dexamethasone in reducing pain and swelling after third molar surgery: a prospective study. J Maxillofac Oral Surg. 2013 Mar; 12(1): 73–9.