ISSN 2415-3060 (print), ISSN 2522-4972 (online)
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УЖМБС 2019, 4(6): 166–170
https://doi.org/10.26693/jmbs04.06.166
Clinical Medicine

Condition of Cardiovascular System in Children with Mitral Valve Prolapse and its Response to Physical Activity

Kuleshov O., Medrazhevska Y., Fik L., Andrikevych I., Shalamai M.
Abstract

Examination of functional condition of cardiovascular system in children with mitral valve prolapse is widely used in modern scientific studies. The purpose of the study was to examine the physical activity effect on the condition of cardiovascular system in children with mitral valve prolapse of the first degree. Material and methods. We examined 90 children aged from 13 to 17 years with mitral valve prolapse of the 1st degree. The control group consisted of 23 almost healthy children of the same age. All teenagers underwent the echocardiography with estimation of the main parameters before and after the physical activity test. Echocardiography was performed when patients were lying on the back. Test with the physical activity was applied as the climbing a step with 1.5 and 3 minutes tempo. The test was carried out within 4 stages: raising the left leg, raising the right leg, lowering the left leg, lowering the right leg. Results and discussion. The original heart rate (73.21±1.15) did not significantly differ from the normative parameters of a similar group of healthy children of the same age. The left ventricular ejection fraction at the beginning was 66.97±0.69, while the shortening fraction of the left ventricular was 36.56±0.87 (%). During the physical activity there was a significant increase of these indicators, relative to the source data. In this case, the mean values of the left ventricular ejection fraction (72.3±1.18, p<0.05) changed statistically and significantly. In addition, there was a tendency to increasing of the shortening fraction of the left ventricular (38.42±0.94) relative to the initial data. The stroke volume in patients with mitral valve prolapse was also increased after exercises (64.27±1.89 vs 70.65±1.9, p<0.05). Conclusion. There was an increase in heart rate with a decrease of the terminal systolic volume and two variants of the terminal diastolic volume of the left ventricular (increasing and stability) and increasing of the left ventricular ejection fraction in children with mitral valve prolapse in response to physical activity. These mechanisms provided improving of the left ventricular emptying. Method of testing children with mitral valve prolapse by exercises, using echocardiography, allows revealing the response of the heart to the physical activity, to assess its condition and to create the appropriate algorithm of preventive measures for prevention of complications.

Keywords: children, mitral valve prolapse, echocardiography, physical exercises

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References
  1. Klemenov AV. Prolaps mitralnogo klapana: sovremennyie predstavleniya i nereshennyie voprosyi (obzor) [Mitral valve prolapse: Current Views and Challenges]. Sovremennyie tehnologii v meditsine. 2017; 9(3): 126-37. [Russian] https://doi.org/10.17691/stm2017.9.3.17
  2. Kulniyazova GM, Davidovich SG, Seypenova AN, Sauleeva FS. Optimizatsiya diagnostiki prolapsa mitralnogo klapana i osobennosti ego techeniya v detskom vozraste. Arhiv' vnutrenney meditsinyi. 2015; 3(23): 14-7. [Russian]
  3. Delling FN, Vasan RS. Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation. 2014; 129(21): 2158–70. https://www.ncbi.nlm.nih.gov/pubmed/24867995. https://www.ncbi.nlm.nih.gov/pmc/articles/4052751. https://doi.org/10.1161/CIRCULATIONAHA.113.006702
  4. Boudoulas KD, Boudoulas H. Floppy mitral valve (FMV)/mitral valve prolapse (MVP) and the FMV/MVP syndrome: pathophysiologic mechanisms and pathogenesis of symptoms. Cardiology. 2013; 126(2): 69–80. https://www.ncbi.nlm.nih.gov/pubmed/23942374. https://doi.org/10.1159/000351094
  5. Guy TS, Hill AC. Mitral valve prolapse. Annual review of medicine. 2012; 63(1): 277–92. https://www.ncbi.nlm.nih.gov/pubmed/22248324. https://doi.org/10.1146/annurev-med-022811-091602
  6. Althunayyan A, Petersen SE, Lloyd G, Bhattacharyya S. Mitral valve prolapse. Expert review of Cardiovascular Therapy. 2019 Jan; 17(1): 43-51. https://www.ncbi.nlm.nih.gov/pubmed/30484338. https://doi.org/10.1080/14779072.2019.1553619
  7. Basso C, Iliceto S, Thiene G, Perazzolo Marra M. Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death. Circulation. 2019; 140(11): 952-64. https://www.ncbi.nlm.nih.gov/pubmed/31498700. https://doi.org/10.1161/CIRCULATIONAHA.118.034075
  8. Sharyikin AS, Kolesnikova MA, Shilyikovskaya EV, Ivanova YuM, Pavlov VI. Nagruzochnyie testyi s ehokardiografiey: fiziologicheskie aspektyi. Pediatriya. 2010; 89(3): 112-5. [Russian]
  9. Kuz`menko TV. Proba z dozovanny`m fizy`chny`m navantazhennyam pid kontrolem exokardiografiyi u ditej ta pidlitkiv. Kryimskiy zhurnal eksperimentalnoy i klinicheskoy meditsinyi. 2011; 1(1): 89-92 [Ukrainian]
  10. Gati S, Malhotra A, Sharma S. Exercise recommendations in patients with valvular heart disease. Heart. 2019 Jan; 105(2): 106-10. https://doi.org/10.1136/heartjnl-2018-313372
  11. Sharykin AS, Shilykovskaya YeV, Kolesnikova MA, Pavlov VI, Ivanova YuM, Popova NE. Izmeneniye sistolicheskoy funktsii levogo zheludochka u deteysportsmenov v otvet na fizicheskuyu nagruzku [Changes in systolic function of the left ventricle in children of athletes in response to physical activity]. Rossiyskiy vestnik perinatologii i pediatrii. 2010; (5): 83-9. [Russian]
  12. Kuleshov OV. Funktsionalnyi stan sertsevo-sudynnoi systemy u ditei z prolapsom mitralnoho klapana [The functional state of the cardiovascular system in children with mitral valve prolapse] . Mezhdunarodnyy zhurnal pediatrii, akusherstva i ginekologii. 2012; 2(2): 56-60. [Ukrainian]
  13. Rowland T, Mannie E, Gawie L. Dynamics of left ventricular diastolic filling during exercise. A Doppler echocardiographic study of boys 10 to 14 years old. Chest. 2001; 120:145-50. https://doi.org/10.1378/chest.120.1.145