Nowadays, peritonitis is one of the severest complications of acute inflammatory diseases of the abdominal cavity with a high mortality rate. Endogenous intoxication is an inseparable and threatening link in the peritonitis pathogenesis, and erythrocyte and leukocyte intoxication indices are informative indicators for the study of its development. The purpose of the study was to investigate erythrocytic and leukocyte intoxication index in the peritonitis pathogenesis. Material and methods. All the animals under study were divided into two groups: the 1st group included 25 intact animals; the 2nd group encompassed 50 rats with simulated fecal peritonitis. Fecal peritonitis was modeled using injection of 10% fecal suspension in a dose of 0.5 ml per 100 g of animal weight in the abdominal cavity of laboratory animals by puncture method (Lazarenko V.A., et al., 2016, patent No. 233826). Results and discussion. We considered the changes in erythrocyte intoxication index in animals in details to see what had simulated peritonitis. At the beginning of the first day it was set to increase by 82% compared to the control group. By the end of the first day an increase in the erythrocyte intoxication index was established by 99.5%. On the third day, we revealed the progression of endogenous intoxication in the experimental peritonitis pathogenesis. Animals of the study group did not survive until the 21st day. There was a unidirectional trend with the dynamics of erythrocyte index in experimental conditions and leukocyte intoxication index had significant increase in the marker on the background of modeled peritonitis. It should be noted that leukocyte intoxication index was more sensitive than the erythrocyte index to pathological changes caused by modeled peritonitis. Thus, at the beginning of the 1st day, leukocyte intoxication index was increased by 197.4 % and by the end of the 1st day – by 236.8% in comparison with the intact animals’ data. On the 3rd day, the increase in leukocyte intoxication index was slightly less pronounced compared to the dynamics at the end of the 1st day, but its increase remained significant – by 222.9% (compared to the data of the 1st group). Conclusion. The study revealed unidirectional tendency of erythrocyte and leukocyte intoxication indices changes in the study of pathological changes of laboratory animals organism caused by experimental peritonitis. The obtained data also showed an increased erythrocyte intoxication index in the experimental fecal peritonitis pathogenesis. Most pronounced increase in erythrocyte intoxication index was found on the 3rd day. Increased leukocyte intoxication index proved to be an informative marker of the development of endogenous intoxication in modeled peritonitis, the increase of which was the most pronounced at the end of the 1st day. The leukocyte intoxication index appeared to be more sensitive than erythrocyte intoxication index.

Keywords: fecal peritonitis, experiment, dynamics, leukocyte intoxication index, erythrocyte intoxication index

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