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УЖМБС 2019, 4(2): 14–20
https://doi.org/10.26693/jmbs04.02.014
Medicine. Reviews

Relationship of Periodontal Diseases with Metabolic Syndrome

Batig V. M., Glushenko T. A.
Abstract

The article presents the review of professional literature dealing with the important medical and social problem – the periodontal disease which arises and progresses on the background of a metabolic syndrome. According to the WHO, a metabolic syndrome is called "a noninfectious epidemy of XXI century" due to its high prevalence, which reaches 25-30% of the adult population and has attracted the attention of doctors all over the world. The concept of metabolic syndrome includes tissue insulin-resistance, hypertriglyceridemia, reduction of high density lipoprotein cholesterol and hypertension. Metabolic syndrome leads to abnormal metabolism of proteins, fats and carbohydrates, and hyperglycemia arises, which in turn can provoke many systemic pathologies. There are many chronic pathological processes associated with the development of long-term hyperglycemia and cardiovascular often isolated violations and periodontal disease. Like diseases of the cardiovascular system, periodontal disease, complicated by a diabetic condition, has a more aggressive course and development. The main factor in the formation of metabolic syndrome is insulin resistance, which leads to severe cardiovascular disorders such as myocardial infarction, stroke, localization of vascularization in periodontal tissues, which not only provide the onset, but may complicate the course and treatment of periodontal diseases. Therefore, it is necessary to take into account all these aspects when planning the periodontal treatment of this group of patients. Periodontitis is an infectious-conditioned illness that provokes in most cases gram-negative microorganisms of a biofilm. In the manifestations of periodontal disease, the presence of not only a microbial factor, but also a sensitive substrate, which will give an immune response, is required. In turn, the immune response leads to the violation of the parodontium structural state, and, as a consequence, the emergence of periodontitis. Conclusions. Abnormal inflammatory response, which is inflammation by hipertypom, associated with diabetes, metabolic syndrome, also increased sensitivity to infections such as periodontal disease. Metabolic syndrome is at the heart of disorders of carbohydrate metabolism, atherosclerosis, arterial hypertension, which nowadays acquires not only medical but also social significance. This inflammatory periodontal degenerative changes are in relation to factors such as the age of patients, severity of somatic diseases, adequate preventive measures.

Keywords: metabolic syndrome, periodontal disease

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References
  1. Bodnar PM, Skrypnyk NV. Metabolichnyy syndrom: patohenez, diahnostyka ta likuvannya. Endokrynolohiya. 2010; 15(2): 295-304. [Ukrainian]
  2. Pozharytskaya MM, Symakova TH, Seltsev LK, Kyryenko VV. Vospalytelnye zabolevanyya parodonta u bolnykh s metabolycheskym syndromom. Stomatolohyya. 2004; 83(6): 13–6. [Russian]
  3. Zabolotnyy TD, Borysenko AV, Markov AV, Shylivskyy IV. Heneralizovanyy parodontyt. Lviv: HalDent; 2011. 240 p. [Ukrainian]
  4. Gudaryan AA. Chastota i osobennosti klinicheskikh proyavleniy generalizovannogo parodontita pri razlichnykh komponentakh metabolicheskogo sindroma. Visnik stomatologiyi. 2003; 1: 20-2. [Russian]
  5. Denga AE, Pіndus TA, Denga EM. Densitometricheskie pokazateli kachestva kosti pri khronicheskom generalizovannom parodontite na fone metabolicheskogo sindroma. EESJ. 2018; 3(31): 30-2. [Russian]
  6. Dyenha OV, Pіndus TA, Shnayder SA. Pokaznyky zhyrovoi masy tila pry khronichnomu heneralizovanomu parodontyti na foni metabolichnoho syndromu. Klinichna stomatolohiya. 2018; 1: 9-12. [Ukrainian]
  7. Zvenyhorodskaya LA. Metabolycheskyy syndrom: osnovy patoheneza, yssledovanye v budushchem. Eksper y klyn hastroenterolohyya. 2007; 1: 5-7. [Russian]
  8. Mitchenko OI, Romanov VYu. Optymizatsiya likuvannya ta korektsiya sertsevosudynnoho ryzyku u patsiyentiv iz arterialnoyu hipertenziyeyu ta metabolichnym syndromom. Ukrainskyy medychnyy chasopys. 2015; 2(106): 667–70. [Ukrainian]
  9. Mylytsya KM, Mylytsya MM, Postolenko MD. Multydystsyplinarnyy pidkhid do terapiyi metabolichnoho syndromu ta ozhyrinnya yak zaporuky efektyvnosti yikhnoho likuvannya. Simeyna medytsyna. 2015; 4(60): 38–40. [Ukrainian]
  10. Pasechnik AV, Moiseeva EG, Frolov VA, Drozdova GA. Parodontit i metabolicheskie narusheniya. Uchebno-metodicheskoe posobie. M; 2011. 30 p. [Russian]
  11. Pindus TA, Denga OV, Bubnov VV. Aktivnost tsitokinov IL-1β i IL-2 u patsientov s khronicheskim generalizovannym parodontitom na fone metabolicheskogo sindroma. Scientific pages. 2017; 7: 18-20. [Russian]
  12. Pindus TA, Denga AE, Tkachenko EK. Korrektsiya narusheniy v syvorotke krovi i tkanyakh polosti rta krys pri modelirovanii metabolicheskogo sindroma. EESJ. 2018; 1(29): 21-4. [Russian]
  13. Pindus TA, Denga OV. Rasprostranyonnost i struktura osnovnykh stomatologicheskikh zabolevaniy u patsientov s metabolicheskim sindromom. Innovatsii v stomatologii. 2017; 1: 53-7. [Russian]
  14. Povoroznyuk VV, Mazur IP. Kostnaya sistema i zabolevaniya parodonta. Kiev: Kniga plyus; 2004. 445 p. [Russian]
  15. Prodanchuk AI. Zabolevaniya parodonta i somaticheskaya patologiya. Molodoy uchenyy. 2015; 6: 290-3. [Russian]
  16. Rekomendatsii ekspertov Vserossiyskogo nauchnogo obshchestva kardiologov po diagnostike i lecheniyu metabolicheskogo sindroma. Vtoroy peresmotr. Prakticheskaya meditsina. 2010; 5(44): 81–105. [Russian]
  17. Romanenko IG, Kryuchkov DYu. Generalizovannyy parodontit i metabolicheskiy sindrom. Edinstvo patogeneticheskikh mekhanizmov razvitiya. Krimskiy terapevtichniy zhurnal. 2011; 1: 60-7. [Russian]
  18. Rutovskyy YaA, Kachmarska MO. Metabolichnyy syndrom, tsukrovyy diabet: epidemiolohiya i naslidky dlya zdorov’ya. Ukraina. Zdorov’ya natsiyi. 2012; 2(22): 163-7. [Ukrainian]
  19. Sokolova II, Saveleva NN. Rol vozrastnogo faktora v razvitii zabolevaniy parodonta. Eksperim klin meditsina. 2013; 2(59): 164-9. [Russian]
  20. Starikova IV, Chaplieva EM, Patrusheva MS, i dr. Sravnitelnaya kharakteristika pokazateley mestnogo immuniteta bolnykh khronicheskim generalizovannym parodontitom na fone arterialnoy gipertenzii i metabolicheskogo sindroma. Sovremennye problemy nauki i obrazovaniya. 2015; 3. Available from: http://www.scienceeducation. ru/ru/article/view?id=20186 [Russian]
  21. Tkachenko VI, Bahro TO, Vydyborets NV, Bondar OK. Metabolichnyy syndrom: diahnostyka ta profilaktyka v praktytsi simeynoho likarya. Liky Ukrainy. 2016; 1-2: 43-6. [Ukrainian]
  22. Khoruzhaya RE, Pedorets LP, Barkalova EI. Vyyavlenie somaticheskogo neblagopoluchiya u bolnykh stradayushchikh parodontitom. Vestnik neotlozhnoy i vosstanovitelnoy meditsiny. 2006; 4: 592-5. [Russian]
  23. Tsepov LM, Nikolaev AI, Zhazhkov EN. K voprosu ob etiologii i patogeneze vospalitelnykh zabolevaniy parodonta. Parodontologiya. 2000; 2: 9-13. [Russian]
  24. Shnayder SA, Levitskiy AP. Eksperimentalnaya stomatologiya. Ch. I. Eksperimentalnye modeli stomatologicheskikh zabolevaniy. Odessa: KP «Odeska miska drukarnya»; 2017. 167 p. [Russian]
  25. Ahn YB, Shin MS, Han DH, Sukhbaatar M, Kim MS, Shin HS, et al. Periodontitis is associated with the risk of subclinical atherosclerosis and peripheral arterial disease in Korean adults. Atherosclerosis. 2016; 251: 311-8. https://www.ncbi.nlm.nih.gov/pubmed/27450785. https://doi.org/10.1016/j.atherosclerosis.2016.07.898
  26. Amirkalali B, Fakhrzadeh H, Sharifi F, Kelishadi R, Zamani F, Asayesh H, et al. Prevalence of Metabolic Syndrome and Its Components in the Iranian Adult Population: A Systematic Review and Meta-Analysis. Iran Red Crescent Med J. 2015; 17(12); e24723. https://www.ncbi.nlm.nih.gov/pubmed/26756015. https://www.ncbi.nlm.nih.gov/pmc/articles/4706734. https://doi.org/10.5812/ircmj.24723
  27. Azuma K, Adachi Y, Hayashi H, Kubo KY. Chronic Psychological Stress as a Risk Factor of Osteoporosis. J UOEH. 2015; 37(4): 245-53. https://www.ncbi.nlm.nih.gov/pubmed/26667192. https://doi.org/10.7888/juoeh.37.245
  28. Balarini CM, Braga VA. Editorial: New Translational Insights on Metabolic Syndrome: Obesity, Hypertension, Diabetes and Beyond. Front Physiol. 2016; 7: 229. https://www.ncbi.nlm.nih.gov/pubmed/27375501. https://www.ncbi.nlm.nih.gov/pmc/articles/4901063. https://doi.org/10.3389/fphys.2016.00229
  29. Bhattacharya PT, Misra SR, Hussain M. Nutritional Aspects of Essential Trace Elements in Oral Health and Disease: An Extensive Review. Scientifica (Cairo). 2016; 2016: 5464373. https://www.ncbi.nlm.nih.gov/pubmed/27433374. https://www.ncbi.nlm.nih.gov/pmc/articles/4940574. https://doi.org/10.1155/2016/5464373
  30. Chauhan A, Yadav SS, Dwivedi P, Lal N, Usman K, et al. Correlation of serum and salivary cytokines level with clinical parameters in metabolic syndrome with periodontitis. J Clin Lab Anal. 2016; 30: 649-55. https://doi.org/10.1002/jcla.21917
  31. Maret W. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes. Met Ions Life Sci. 2019 Jan14; 19: pii: /books/9783110527872/9783110527872-015/9783110527872-015.xml. https://www.ncbi.nlm.nih.gov/pubmed/30855110. https://doi.org/10.1515/9783110527872-015
  32. De Sousa SM, Norman RJ. Metabolic syndrome, diet and exercise. Best Pract Res Clin Obstet Gynaecol. 2016 Nov; 37: 140-51. https://www.ncbi.nlm.nih.gov/pubmed/26972165. https://doi.org/10.1016/j.bpobgyn.2016.01.006
  33. Martinez-Miller EE, Kohl HW 3rd, Barlow CE, Willis BL, De Fina LF. Metabolic Syndrome and Cognitive Impairment among High Socioeconomic, Nondemented Older US Adults. J Am Geriatr Soc. 2019 Mar 10. https://www.ncbi.nlm.nih.gov/pubmed/30854644. https://doi.org/10.1111/jgs.15836
  34. Raja Kumar S, Mohd Ramli ES, Abdul Nasir NA, Ismail NHM, Mohd Fahami NA. Preventive Effect of Naringin on Metabolic Syndrome and Its Mechanism of Action: A Systematic Review. Evid Based Complement Alternat Med. 2019 Feb 3; 2019: 9752826. Collection 2019. Review. https://www.ncbi.nlm.nih.gov/pubmed/30854019. https://doi.org/10.1155/2019/9752826.
  35. Sung KC, Ryu S, Lee JY. Fatty Liver, Insulin Resistance, and Obesity: Relationships With Increase in Coronary Artery Calcium Over Time. Clin Cardiol. 2016; 39(6): 321-8. https://doi.org/10.1002/clc.22529
  36. Frisbee JC, Goodwill AG, Frisbee SJ, Butcher JT, Wu F, Chantler PD. Microvascular perfusion heterogeneity contributes to peripheral vascular disease in metabolic syndrome. J Physiol. 2016; 594(8): 2233-43. https://www.ncbi.nlm.nih.gov/pubmed/25384789. https://www.ncbi.nlm.nih.gov/pmc/articles/4933102. https://doi.org/10.1113/jphysiol.2014.285247