Hysterectomy is the most common gynecological surgery in most countries which is performed for women in perimenopause. Post ovariectomy syndrome is characterized for women with this problem, which is manifested as vegetative-vascular, psycho-endocrine and metabolic disorders. Deficiency of female sex hormones, due to ovariectomy, initiates and promotes the development of mutually aggravating progression of metabolic disorders such as atherogenic dyslipidemia, insulin-dependent diabetes mellitus, hyperuricemia, lack of calcium-phosphorus metabolism. In this regard, it is especially important to study various disorders that develop as a result, or against post ovariectomy syndrome. Up to date, work on the study of post ovariectomy syndrome against the background of endocrine disorders, including diabetes is insufficient. Further maintenance and treatment of these patients requires careful examination of both the surgery and in the postoperative period. The aim is to analyze the biochemical parameters and hormonal profile of women of late reproductive age with diabetes mellitus in the pre-surgical period. Materials and methods. There were 91 patients under observation with diabetes, who received hysterectomy on benign diseases, of these 91 patients 27 patients were with diabetes mellitus (DM) type I and referred to the group 1, and 34 women with type II diabetes in group 2. The average age of patients in groups was about 45,7 ± 7,09 and 47,1 ± 1,09 (р>0,05). The control group consisted of 30 healthy women almost without endocrine and gynecological diseases. All women held collect anamnesis, conventional clinical laboratory tests, biochemical examinations. Glycosylated hemoglobin was determined and conducted an assessment of the hormonal profile, to evaluate the bone X-ray was performed. Statistical analysis of the data conducted using STATISTICA 6 program. Results and discussion. At the initial examination, the most surveyed women of both groups complained of periodic headaches, psycho-emotional disability that manifested irritability and rapid change of mood. All surveyed women had metabolic disorders which are characterized by increased levels of total cholesterol, α-amylase, low density of lipoprotein compared with the control group, while in patients with diabetes of the first type levels of urea, triglycerides and lipoprotein were significantly increased than in patients of control group. In the first group of women glycosylated hemoglobin in the process of compensation determined at 92% compared to the second group of women (83%), subcompensation - 5% and 10%, decompensation - 3% and 7% respectively. Analyzing test results hormone profile revealed a significant increase in levels of testosterone and progesterone in women with diabetes mellitus of both types compared with healthy women, except in the first group of women slightly increased levels of LH and FSH compared with women in the control group (p <0,05) . Conclusions. Received data of this problem and the severity of metabolic disorders that develop as a result of surgical castration, methods in the pre surgical period should be more carefully defined which allow preventing the development of disorders of metabolic processes, the functioning of the endocrine, nervous, cardiovascular and other systems, in time making the appropriate choice of drug therapy and rehabilitation measures.
Keywords: hysterectomy, late reproductive age women, diabetes mellitus, surgical menopause
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