The purpose of the study was to determine the relationship between clinical and psychopathological features of the leading symptom complexes and features of cognitive dysfunction in patients with bipolar affective disorder. Material and methods. The study involved 141 patients with bipolar affective disorder. The study of clinical and psychopathological features of depressive disorders included the analysis of the leading symptom complexes and clinical manifestations of depression in patients with bipolar affective disorder. The study of the features of cognitive dysfunctions in depressive disorders included an analysis of the severity of cognitive disorders and features of cognitive processes (mental, mnestic, attention, perception), executive functions and the specifics of social functioning in patients with bipolar affective disorder. Results and discussion. The study result showed that majority of patients had a predominance of asthenic-energetic, apathetic-adynamic and melancholic symptom complexes. According to the results of the research, a correlation analysis was performed, which allowed to determine the combination of clinical and psychopathological symptoms with the peculiarities of the cognitive functioning of patients with bipolar affective disorder. As a result of correlation analysis it was found that the apathic-adynamic symptom complex was associated with low work efficiency, decreased interest, difficulties in decision-making, severe impairment of executive functions and verbal productivity, rumination, moderate impairment of visual-motor coordination, decreased concentration, switching and attention stability, significant impairments in the areas of socially useful activities, personal and social interaction and self-service. The astheno-energetic symptom complex was associated with exhaustion of mental activity, a decreased level of delayed reproduction, difficulties in decision-making, low work efficiency, a low level of performance, a decrease in the level of short-term memory, moderate impairments in socially useful activities and self-care. Conclusion. The melancholic symptom complex correlated with self-accusation, catastrophization, moderate impairment of executive functions, a decrease in the level of attention switching, a low level of efficiency, an average selectivity of attention to negative stimuli, pronounced impairments of executive functions and verbal productivity. Dysphoric symptom complex was associated with blaming others, increased sensitivity to criticism, decreased concentration and stability of attention, average selectivity of attention to negative stimuli, and significant aggressive patterns of behavior

Keywords: cognitive impairment, depressive disorders, clinical and psychopathological features, symptom complex, bipolar affective disorder

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1. Osnovnye svedeniya o depressii: informatsionnyy byulleten VOZ [Key facts about depression: WHO fact sheet]. 2017. [Russian] Available from: http://www.who. int/mediacentre/factsheets/fs369/ru/
2. Kozhevnikova IS, Gribanov AV, Pankov MN, Startseva LF, Tikhonova EV. Neyrofiziologicheskie korrelyaty depressivnykh rasstroystv (obzor literatury) [Neurophysiological correlates of depressive disorders (literature review)]. Ekologiya cheloveka. 2017; 12: 26-32. [Russian] https://doi.org/10.33396/1728-0869-2017-12-26-32
3. Verbenko GN. Osobennosti kognitivnykh narusheniy u patsientov s bipolyarnym affektivnym rasstroystvom [Features of cognitive impairment in patients with bipolar disorder]. Tavricheskiy zhurnal psikhiatrii. 2014; 1(66): 18-23. [Russian]
4. Shmukler AB. Kognitivnye narusheniya v strukture depressivnogo sindroma [Cognitive impairments in the structure of depressive syndrome]. Sotsialnaya I klinicheskaya psikhiatriya. 2016; 26(1): 72-76. [Russian]
5. Sole B, Martinez-Aran A, Torrent C. Are bipolar II patients cognitive impairment? A systematic review. Psychol Med. 2011; 41(9): 1791-1803. https://doi.org/10.1017/S0033291711000018
6. Pidkoritov VS, Syerikova OI, Skrinnik OV, Ukrainskiy SO, Serikova OS. Kohnitivni funktsiyi pri zmishanomu epizodi bipolyarnoho afektivnoho rozladu [Cognitive functions in case of a small episode of bipolar affective breakdown]. Psikhiatriya, nevrolohiya ta medichna psikholohiya . 2019; 12: 8-16. [Ukrainian] https://doi.org/10.26565/2312-5675-2019-12-01
7. Serna E, Vila M, Sanchez-Gistau V. Neuropsychological characteristics of child and adolescent off spring of patients with bipolar disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2016; 65: 54-9. https://doi.org/10.1016/j.pnpbp.2015.08.014
8. Bora E, Pantelis C. Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls. Schizophrenia Bulletin. 2015; 41(5): 1095-104. https://doi.org/10.1093/schbul/sbu198
9. Shmukler AB. Kognitivnye narusheniya v strukture depressivnogo sindroma [Cognitive impairments in the structure of depressive syndrome]. Sotsialnaya i klinicheskaya psikhiatrii. 2016; 26(1): 72-76. [Russian]
10. Samame C, Martino DJ, Strejilevich SA. Longitudinal course of cognitive deficits in bipolar disorder: a meta-analytic study. Journal of Aff ective Disorders. 2014; 164: 130-38. https://doi.org/10.1016/j.jad.2014.04.028
11. Ershov BB, Tagiltseva AV, Petrov MV. Sovremennye issledovaniya kognitivnogo defitsita pri affektivnykh rasstroystvakh: neyropsikhologicheskiy podkhod (obzor literatury) [Modern research on cognitive deficits in affective disorders: a neuropsychological approach (literature review)]. Vestnik Yuzhno-Uralskogo gosudarstvennogo universiteta. Seriya: Psikhologiya. 2015; 8(3): 65-76. [Russian]
12. Halvorsen M, Hoifodt RS, Myrbakk IN. Cognitive function in unipolar major depression: a comparison of currently depressed, previously depressed, and never depressed individuals. J Clin Exp Neurops. 2012; 34(70): 782-90. https://doi.org/10.1080/13803395.2012.683853
13. Krasnov VN, Alfimova VM, Melnikova TS. Vzaimosvyazi kognitivnykh i emotsionalnykh narusheniy pri depressiyakh (obzor literatury) [The relationship between cognitive and emotional disorders in depression (literature review)]. Doktor.Ru. 2013; 5(83): 70-76. [Russian]
14. Antonyuk T. Novi pidkhodi do kuratsiyi bipolyarnogo rozladu [New approaches to the treatment of bipolar disorder]. Za materialami shchorichnoyi naukovo-praktichnoyi konferentsiyi z mizhnarodnoyu uchastyu «Ukrayinska psikhiatriya v sviti, shcho shvidko zminyuyetsya» (25–27 kvitnya 2018 r., Kiyiv, Ukrayina). Нейроnews. 2018; 4-5(97): 24-26. [Ukrainian]
15. Maruta NO, Verbenko GM. Kognitivni porushennya u khvorikh na bipolyarniy afektivniy rozlad [Cognitive disorders in patients with bipolar disorder]. Nevrologiya, Psikhiatriya, Psikhoterapiya . 2017; 3 (42): 32-34. [Ukrainian]
16. Kolyagin VV. Bipolyarnoe affektivnoe rasstroystvo: posobie dlya vrachey [Bipolar Affective Disorder: A Guide for Physicians]. V 2 ch. Part 1. Irkutsk: RIOGBOU DPOIGMAPO; 2015. 56 с. [Russian]