ISSN 2415-3060 (print), ISSN 2522-4972 (online)
  • 27 of 67
JMBS 2020, 5(4): 202–208
Clinical Medicine

Prognostic Value of Caspase-1, Interleukin-1β, Tumor Necrosis Factor-α and Interleukin-18 Activity in Patients with Gastroesophageal Reflux Disease and Autoimmune Thyroiditis

Pasiieshvili T. M., Kovaloyva O. M., Pasiieshvili L. M., Zhelezniakova N. M.

In recent years, the attention of scientists and clinicians has been attracted by the problem of the combined course of the most common chronic diseases of internal organs. Particular attention is paid to their occurrence in young people. Among such diseases, there are autoimmune thyroiditis and gastroesophageal reflux disease. Many factors contribute to their occurrence in young people which is caused by chronic stress, the spread of viral diseases, lack of food culture, crowded groups and the like. The purpose of the work was to study the manifestations of systemic inflammation according to a content of caspase-1, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18) in the blood serum of young patients with gastroesophageal reflux disease and autoimmune thyroiditis and their role in the formation of clinical remission. Material and methods. The study involved 120 patients with gastroesophageal reflux disease and autoimmune thyroiditis, 45 people with isolated gastroesophageal reflux disease and 42 patients with autoimmune thyroiditis. The content of caspase-1, IL-1β, TNF-α and IL-18 was studied in blood serum by ELISA. Results and discussion. Determining the content of caspase-1, IL-1β, TNF-α and IL-18 showed a significant increase due to a pro-inflammatory genetically determined response in all groups. The activity of these cytokines depended on the nosological form and was maximum with a combination of gastroesophageal reflux disease and autoimmune thyroiditis. After 2 months from the start of treatment, on the background of the preservation of the vegetative manifestations of diseases, we determined an increase in the activity of pro-inflammatory cytokines with positive dynamics to their reduction. This circumstance can be the result of both an autoimmune component in thyroiditis and the development of endothelial dysfunction. Conclusion. Standard therapy in patients with gastroesophageal reflux disease and autoimmune thyroiditis leads to leveling of clinical symptoms, but is not accompanied by signs of morphological remission. This circumstance causes the implementation of lengthy rehabilitation measures.

Keywords: gastroesophageal reflux disease, autoimmune thyroiditis, pathogenesis, cytokines

Full text: PDF (Ukr) 210K

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