Chronic tonsillitis possesses a peculiar place in otolaryngology. Somatic diseases associated with tonsillitis are characterized by a prolonged, intermittent course and lead to partial disability and disability of persons of working age. Finding perfect methods for laboratory evaluation of the degree of the pathological process in patients with chronic tonsillitis is an urgent question in otolaryngological practice. The purpose of our study was to investigate the functional activity of platelet and indices of the coagulative link of hemostasis system in patients with decompensated form of chronic tonsillitis. Material and methods. We examined 30 patients who were hospitalized in the department of inflammatory diseases of ENT organs of the State Institution «O. S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Sciences of Ukraine». The control group consisted of 20 healthy persons. Platelet aggregation was studied using аdenosine diphosphate as inductor at final concentrations of 1.25, 2.5 and 10 μmol/l. Results and discussion. To evaluate the aggregation process, the degree, the rate and the reaching time of the maximum aggregation were determined. Thrombin-like activity, fibrinogen concentration and von Willebrand factor level were studied. Patients with chronic tonsillitis have pronounced changes in the degree and rate of platelet aggregation toward increasing their levels relative to the indices of a control group. The increase in the time of platelet aggregation at the lowest and medium concentrations of аdenosine diphosphate and its reduction at the highest one can indicate the decrease function of the platelet. The increase of amidolytic thrombin-like activity, fibrinogen levels and von Willebrand factor were shown, which is a manifestation of the inflammatory process and may be the one of the reasons for increase of the platelet aggregation. Conclusion. Our results indicate the necessity for laboratory studies of platelet activity and indicators of the coagulation link of the hemostasis system in patients with chronic tonsillitis to detect changes in the hemostasis system associated with an increased risk of operative bleeding and take measures to prevent them. Moreover, the studies of platelet activity can be used for the development of objective criterions for evaluation of the severity of the inflammatory process at the chronic tonsillitis.

Keywords: tonsillitis, platelet aggregation, thrombin-like activity, fibrinogen, von Willebrand factor

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