ISSN 2415-3060 (print), ISSN 2522-4972 (online)
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JMBS 2020, 5(2): 36–42
Medicine. Reviews

Mechanisms of Macro-, Micro- and Ultramicroscopic Transformation of Bodies in Type 2 Diabetes

Savka I. I., Savka T. B.

The study of structural changes of organs and tissues in the context of diabetes is one of the urgent problems of modern medicine. According to WHO, the number of patients with diabetes exceeds 175 million people in all countries of the world. According to an expert estimate of the spread of this disease by 2025 will have made about 300 million people. More than 1 million people with diabetes have been officially registered in Ukraine. WHO has recognized the disease as a non-communicable epidemic. The dramatic increase in the prevalence of diabetes requires a detailed study of this problem. The article represents analysis of works of numerous researchers who studied statistіcal, clinical and morphological aspects of the impact of diabetes on cardiovascular system. Main morphogenetic, morphological and clinical aspects of complications of diabetes, pathologies of microcirculation of patients with diabetes were analyzed in order to predict and detect on the early stages vascular complications in diabetes and to perform effective prevention and treatment. The study showed that the prevalence of diabetes increased among the population of the countries of the world depending on the region, the level of economic development of the country, gender and age. Thus, according to IDF findings, there is a tendency for the highest prevalence of diabetes among the urban (urban) able-bodied population of developing countries in persons between 40 and 59 years of age, approximately equal in both male and female. The number of patients is increasing, mainly due to patients with type 2 diabetes. Type 2 diabetes (type 2 diabetes mellitus) is a severe progressive chronic disease that is an independent risk factor for heart failure and cardiovascular complications. In the XXI century the steady growth of type 2 diabetes and the frequency of its serious consequences are of great concern to the world medical community. It is important that at the time of diagnosis of type 2 diabetes, the prevalence of complications leading to a decline in quality of life, early disability and premature death is already high enough. Conclusion. Despite effective drugs, modern technologies, new educational and preventive techniques, mankind loses the fight against diabetes year after year, which leads to disability due to its complications, reducing the life expectancy and quality of life of patients, loss working capacity and premature mortality. Thus, the current prevalence and incidence of diabetes and life-threatening complications suggest that there is a non-communicable diabetes epidemic in the world and in Ukraine, in particular.

Keywords: organ structure, angiopathy, neuropathy, diabetes mellitus

Full text: PDF (Ukr) 216K

  1. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008; 358(24): 2560–72. PMID: 18539916.
  2. Arutyunyan NM. Ultrazvukovye kryteryy dyagnostyky rannykh proyavlenyy dyabetycheskoy mykroangyopatyy u patsyentov s sakharnym dyabetom 2-go typa [Ultrasound diagnostic criteria for the early manifestations of diabetic microangiopathy in patients with type 2 diabetes]. Ultrazvukovaya y funktsyonalnaya dyagnostyka. 2007; 5: 76–82. [Russian]
  3. Korpacheva-Zinych OV. Androheny i tsukrovyi diabet 2 typu [Androgens and type 2 diabetes]. Endokrynolohiya. 2005; 1: 76–90. [Ukrainian]
  4. Khvorostynka VM, Ylchenko YA, Moyseenko TA. Arteryalnaya gypertenzyya y sakharnyy dyabet. Mekhanyzmy formyrovanyya sosudystykh porazhenyy [Arterial hypertension and diabetes. The mechanisms of the formation of vascular lesions]. Ukrayinskyy terapevtychnyy zhurnal. 2006; 1: 101–4. [Russian]
  5. Prystupyuk OM. Oksydantnyi stres za nayavnosti tsukrovoho diabetu [Oxidative stress in the presence of diabetes]. Ukrainskyi medychnyi chasopys. 2002; 3: 23–5. [Ukrainian]
  6. Alves B, Martins AD, Cavaco JE, Socorro S, Oliveira PF. Diabetes, insulin-mediated glucose metabolism and Sertoli blood-testis barrier function. Tissue barriers. 2013; 1(2): 92-6. PMID: 24665384. PMCID: PMC3875609.
  7. Kikhtyak OP, Skrypnyk NV. Mozhlyvosti vidtvorennya tsukrovoho diabetu v eksperymenti [Ability to reproduce diabetes in an experiment]. Eksperymentalna ta klinichna endokrynolohiya. 2004; 2: 118–20. [Ukrainian]
  8. Capehorn MS, Catarig AM, Furberg JK, Janez A, Price HC, Tadayon S, et al. Efficacy and safety of once-weekly semaglutide 1.0 mg vs once-daily liraglutide 1.2 mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes. Diabetes Metab. 2019; 10(19): pii: S1262-3636(19)30132-6. PMID: 31539622.
  9. Ptashnyk GI. Features of blood supply to the testicles in males shells adulthood. Galytski medicinal journal. 2007; 4: 79–81.
  10. Bolotov Yu. N. Lechebno-dyagnostycheskyy algorytm pry ostrykh zabolevanyyakh yaychka u detey [Diagnostic and treatment algorithm for acute testicular diseases in children]. Detskaya khyrurgyya. 2011; 5:10–13. [Russian]
  11. Hotyur OI. Strukturno-funktsionalni osoblyvosti yayechka ta nad’yayechka u cholovikiv reproduktyvnoho viku (22-35 rokiv) v normi [Structural and functional features of the testicle and epididymis in men of reproductive age (22-35 years) normal]. Halytskyi likarskyi visnyk. 2012; 2: 24–6. [Ukrainian]
  12. Martovytska YuV. Diabetychna mikroanhiopatiya: morfohenez ta rol u rozvytku uskladnen tsukrovoho diabetu [Diabetic microangiopathy: morphogenesis and role in the development of diabetes complications]. Patolohiya. 2008; 3: 6–10. [Ukrainian]
  13. 13. Moebus S, Stang A, Mohlenkamp S, Dragano N, Schmermund A, Slomiany U, et al. Association of impaired fasting glucose and coronary artery calcification as a marker of subclinical atherosclerosis in a population-based cohort. Heinz Nixdorf Recall Study Diabetologia. 2009; 52(8): 81–9. PMID: 18979083.
  14. Hui S, Liu Y, Chen M, Wang X, Lang H, Zhou M, et al. Capsaicin Improves Glucose Tolerance and Insulin Sensitivity Through Modulation of the Gut Microbiota-Bile Acid-FXR Axis in Type 2 Diabetic db/db Mice. Mol Nutr Food Res. 2019; 4(1): 226-9. PMID: 31539192.
  15. Okada H, Tanaka M, Hasegawa G, Nakajima H, Kadono M, Okada Y, et al. Comparison of the efficacy of repaglinide versus the combination of mitiglinide and voglibose on glycemic variability in Japanese patients with type 2 diabetes. Curr Pharm Des. 2019; 9 (3): 20-38. PMID: 31538887.
  16. Østerby R, Hartmann A, Bangstad HJ. Structural changes in renal arterioles in Type I diabetic patients. Diabetologia. 2002; 45(4): 542–9. PMID: 12032631.
  17. Schram MT, Henry RM, van Dijk RA, Kostense PJ, Dekker JM, Nijpels G, et al. Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study. Hypertension. 2004; 43(2): 176–81. PMID: 14698999.
  18. Savka II. Vplyv hiperhlikemiyi na morfometrychnu kharakterystyku stanu anhioarkhitektoniky yayechka shchura [Effect of hyperglycemia on the morphometric characteristics of the rat angioarchitectonics]. Vіsnуk рrоblem bіolohіyi i mеdytsіny. 2016; 2(2): 291-5. [Ukrainian]
  19. Bobyryeva LYe. Vilnoradykalni mekhanizmy poshkodzhennya sudynnoi stinky pry tsukrovomu diabeti [Free radical mechanisms of damage of a vascular wall at a diabetes mellitus]. Endokrynolohiya. 1997; 1: 109–13. [Ukrainian]
  20. Tsiselskyi YuV. Korektsiya za dopomohoyu insulinu hiperhlikemiyi i perekysnoho okysnennya lipidiv u shchuriv z eksperymentalnym tsukrovym diabetom 2 typu [Correction by insulin hyperglycemia and lipid peroxidation in rats with type 2 experimental diabetes mellitus]. Endokrynolohiya. 2007; 2: 287–91. [Ukrainian]
  21. Xie F, Liang Y, Xia Y, Luo S, Jiang F, Fu L. Discovery of 2-ethoxy-4-(methoxymethyl)benzamide derivatives as potent and selective PTP1B inhibitors. Bioorg Chem. 2019; 10(2): 20-30. PMID: 31539748.
  22. Borys RYa. Elektronno-mikroskopichne doslidzhennya hemomikrotsyrkulyatornoho rusla riznykh shariv shkiry biloho shchura pry eksperymentalnomu tsukrovomu diabeti [Electron microscopic examination of the hemomicrocirculatory bed of different layers of white rat skin in experimental diabetes mellitus]. Visnyk morfolohiyi. 2010; 16(1): 63–6. [Ukrainian]
  23. Brodyak IV. Vplyv aminohuanidynu na aktyvnist NO-syntazy v leykotsytakh peryferychnoi krovi za umov streptozototsynovoho diabetu v shchuriv [Effect of aminoguanidine on NO synthase activity in peripheral blood leukocytes under streptozotocin diabetes in rats]. Eksperymentalna fiziolohiya ta biokhimiya. 2006; 3: 45–9. [Ukrainian]
  24. Vernyhorodskyi VS. Kliniko-morfolohichna kharakterystyka sudyn nyzhnikh kintsivok u khvorykh na tsukrovyi diabet II typu [Clinico-morphological characteristics of lower extremity vessels in patients with type II diabetes]. Visnyk morfolohiyi. 2002; 8(2): 222–3. [Ukrainian]
  25. Kryvko YuYa. Zminy ultrastruktury synapsiv i neyroniv perednikh rohiv spynnoho mozku u shchuriv z streptozototsynindukovanym diabetom [Changes in the ultrastructure of synapses and neurons of the anterior horns of the spinal cord in rats with streptozotocin-induced diabetes]. Praktychna medytsyna. 2003; 5: 91–95. [Ukrainian]
  26. Krasnyi MR, Serhiyenko VO, Kovalyshyn VI, Serhiyenko OO. Osoblyvosti ultrastrukturnykh zmin hemokapilyariv nyrkovoi kory shchuriv pry streptozototsynovomu diabeti [Features of ultrastructural changes of hemocapillaries of rat renal cortex in streptozotocin diabetes]. Problemy endokrynnoi patolohiyi. 2006; 3: 39–43. [Ukrainian]
  27. Amann T. Epididymal Sperm Reserves. Sperm Production Bates. Development, anatomy, and physiology. 2012; 2(3): 433.
  28. Ivanova OV, Polorak VV. Halmuyuchyi vplyv rechovyny L-2264 na rozvytok vtorynnoi insulinovoi rezystentnosti u shchuriv iz streptozototsynovym diabetom [The inhibitory effect of substance L-2264 on the development of secondary insulin resistance in rats with streptozotocin diabetes]. Teoretychna i eksperymentalna medytsyna. 2004; 4: 40–3. [Ukrainian]
  29. Cherkasov VH, Kryvko YuYa. Patohenetychni mekhanizmy streptozototsynindukovanoi neyropatiyi ta efekt zastosuvannya nikotynamidu [Pathogenetic mechanisms of streptozotocin-induced neuropathy and the effect of nicotinamide use]. Naukovyi visnyk Natsionalnoho medychnoho universytetu imeni OO Bohomoltsya. 2009; 2(3): 17–22. [Ukrainian]
  30. Sultan RYa, Mateshuk-Vatseba LR, Kryvko YuYa. Osoblyvosti budovy yazyka shchura pry eksperymentalnomu streptozototsynindukovanomu tsukrovomu diabeti [Features of the structure of the rat tongue in experimental streptozotocin-induced diabetes mellitus]. Materialy 8 Konhresu SFULT. 2010; 2010: 672–3. [Ukrainian]
  31. Petriv RB. Ultrastructure and functional changes hemomicrocirculation channel rat testis in term of experimental streptozotozin-induction diabetes. Galytski medicinal journal. 2010; 2: 79–81.
  32. Luchytskyi YeV, Bezverkha TP. Rol sudynnoho chynnyka u porushenni statevoi funktsiyi u cholovikiv, khvorykh na tsukrovyi diabet [The role of vascular factor in sexual dysfunction in men with diabetes mellitus]. Endokrynolohiya. 2006; 1: 55–62. [Ukrainian]
  33. Petriv RB. Ultrastrukturni ta funktsionalni zminy hemomikrotsyrkulyatornoho rusla yayechka statevozrilykh bilykh shchuriv v umovakh eksperymentalnoho streptozototsyn-indukovanoho tsukrovoho diabetu [Ultrastructural and functional changes of the hemomicrocirculatory bed of the testis of pubescent white rats in the conditions of experimental streptozotocin-induced diabetes mellitus]. Halytskyi likarskyi visnyk. 2010; 2: 79–81. [Ukrainian]