ISSN 2415-3060 (print), ISSN 2522-4972 (online)
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JMBS 2019, 4(6): 309–315

Anti–Glycation Aging Prevention Strategies

Boiarska Z.

The article provides overview data on modern theories of aging. Aging is a complex process that occurs under the influence of endogenous and exogenous factors. Among the external factors of skin aging, ultraviolet radiation, xenobiotic effects and poor nutrition have the greatest influence. Particular attention is paid to the consideration of modern biomarkers of skin aging, which allows establishing the type of skin aging, the leading mechanisms of skin aging, and to select an adequate strategy for the prevention of skin aging. Today, biomarkers of aging, such as reactive oxygen species, mitochondrial dysfunction, decreased activity of antioxidant defense mechanisms (due to free radical processes), DNA damage (due to ultraviolet radiation), telomere shortening, and decreased telomerase activity (due to due to chronic aging) and the possibility of increasing their activity. Particular attention is paid to glycation processes, its mechanisms and the role of glycation end products in the development of oxidative and glycation stress. Two directions are distinguished: the search for substances that inhibit the formation of end glycation products, and the search for substances that disrupt the structure of final glycation products. The characteristics of substances are given, they are actively studied in our time and have anti–glycation effects (aminoguanidine, thiamine, pyridoximine, metmorphine, carnosine, α–lipoic acid, plant extracts). The purpose of this work was to determine the main views on the mechanisms of aging and analysis of substances that reduce the glycation of proteins according to literature. Сonclusion. The article proved that, based on the theory of glycation, as one of the modern theories of skin aging, the amount of final glycation products accumulates in the skin, which leads to the development of glycation and oxidative stress and irreversible changes in the structure of collagen and other skin proteins. However, the use of substances that reduce glycation and have antioxidant properties is an important component of programs for the prevention of skin aging and the correction of visible signs of skin aging, and determines the relevance of this review article.

Keywords: aging, glycation, glycic stress, oxidative stress, antiglycants

Full text: PDF (Ukr) 216K

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