In medicine, gastric and intestinal polyps are important because after polypectomy they can appear at their primary location and elsewhere. Anaerobic microorganisms of the large intestine form short-chain fatty acids in the process of metabolism. The composition of short-chain fatty acids is disrupted when changing its microflora. The purpose of the study is to evaluate the efficacy of applying symbiter in combination with surgical treatment in patients with multiple polyps of the stomach and intestines (in terms of fatty acid composition in blood serum). Material and methods. 35 healthy individuals (group I), 61 patients with gastric polyps (group II), and 63 patients with intestinal polyps (group III) were examined. Patients of ІІ A and ІІІ A subgroups were prescribed only traditional surgical treatment, and patients of ІІ B and ІІІ B subgroups took surgical treatment in a complex with Symbiter® acidophilic (0.14 ml / kg, 2 times a day, per os; 28 days). Before and after treatment, the composition of fatty acids of phospholipids in blood serum was determined on a “Svet-500” gas chromatograph with a plasma ionization detector in the isothermal mode. Results and discussion. Fatty acid indices of blood serum improved in patients with polyps in ІІ B and ІІІ B subgroups. In patients of ІІ B and ІІІ B subgroups, the level of margarine fatty acid decreased faster, and the level of oleic, palmitic and stearic fatty acids increased faster, which was noted much slower in patients of ІІ А and ІІІ A subgroups (during surgical treatment without symbiter). Margarine fatty acid disappeared in patients of ІІ B and ІІІ B subgroups, which was not observed in patients of ІІ A and ІІІ A subgroups. The appearance of margarine fatty acid in patients of II and III groups before treatment is due to the presence of bacterial infection in these patients. Patients of II B and III B subgroups disappeared in the course of treatment with margarine fatty acid, which testified to the positive effect of the symbiter on the composition of fatty acids and microflora. In the treatment of II A and III A subgroups patients’ margarine fatty acid were preserved. The level of linoleic fatty acid in patients of II B and III B subgroups and II A and III A subgroups during treatment was maintained at high levels. When using a symbiter, the level of linoleic fatty acid in patients of IIB and IIIB subgroups was not normalized. In the treatment of patients of IIA and IIIA subgroups, a similar situation was noted. The level of oleic fatty acid (C18: 1) significantly (p <0.05) increased in the treatment process in patients of II B and III B subgroups, although it was decreased (p <0.05) compared with healthy subjects. In the treatment of IIA and IIIA subgroups patients, the level of oleic fatty acid (C18: 1) increased unreliably. In patients of II B and III B subgroups, the total content of saturated and unsaturated fatty acids was not normalized during treatment. Conclusion. The use of symbiter in a complex with surgical treatment in patients with multiple polyps of the stomach and intestines was aimed at a quicker correction of changes in the fatty acid (margarine, oleic, palmitic and stearic) composition of lipids in the serum of blood, which in some way increased the effectiveness of treatment of these patients.

Keywords: polyps of the stomach and intestines, fatty acids, blood serum, symbiter, effectiveness of treatment

Full text: PDF (Ukr) 217K

1. Aleksandrova KV, Sinchenko DM, Levich SV. Peretravlennia lipidiv u shlunkovo-kyshkovomu trakti liudyny. Lipoproteiny plazmy krovi. Obmin prostykh lipidiv ta ketonovykh til: metodychnyi posibnyk dlia vykladachiv. Zaporizhzhia: ZDMU; 2016. 91 s. [Ukrainian]
2. Andreeva IV. Potentsialnye vozmozhnosti primeneniya probiotikov v klinicheskoy praktike [The potential application of probiotics in clinical practice]. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2006; 8(2): 151–72. [Russian]
3. Domaratckyi VA. Polіpektomіia u dіtei [Polypectomy in children]. Klіnіchna khіrurhіia. 2003; 8: 63. [Ukrainian]
4. Yerofeev NP, Radchenko VG, Seliverstov PV. Klinicheskaya fiziologiya tolstoy kishki. Mekhanizmy deystviya korotkotsepochechnykh zhirnykh kislot v norme i pri patologii [Clinical physiology of the colon. The mechanisms of action of short-chain fatty acids in health and disease]. SPB: Forte Print; 2012. 56 p. [Russian]
5. Kedyk AV, Rishko MV. Henderni ta vikovi osoblyvosti zhyrno kyslotnoho spektru plazmy krovi u meshkantsiv hirskykh naselenykh punktiv Zakarpatskoi oblasti. Scientific Journal “ScienceRise: Medical Science”. 2018; 6(26): 16–9. [Ukrainian]
6. Pikas PB. Stan mikrobnoi kontaminatsii tovstoi kyshky u khvorykh iz polipamy shlunkovo-kyshkovoho traktu [Condition of microbial contamination of the colon in patients with polyps of the gastrointestinal tract. Visnyk problem biolohii i medytsyny. 2014; 4(115): 170–2. [Ukrainian]
7. Pikas PB. Helicobacter pylori ta polipy shlunka, yikh vzaiemozviazok [Helicobacter pylori and stomach polyps, their interrelationship]. Eksperymentalna i klinichna medytsyna. 2015; 2(67): 129–32. [Ukrainian]
8. Pikas PB. Osoblyvosti metabolichnykh zmin lipidiv u syrovattsi krovi u khvorykh na polipy kyshechnyka i shlunka [Features of metabolic lipid changes in serum of blood in patients with polyps of the intestines and stomach ]. Biomedical and Biosocial anthropology / Biomedychna i biosotsialna antropolohiia. 2016; 27: 149–54. [Ukrainian]
9. Putnikov AV, Holota YuV, Serhiichuk TM, Ostapchuk AM, Zakordonets LV, Ostapchenko L, et al. Kilkisni ta funktsionalni pokaznyky kyshkovoi normo bioty shchuriv. Mikrobiolohiia i biotekhnolohiia. 2015; 2: 89–100. [Ukrainian]
10. Radchenko VG, Suvorov AN, Sitkin SI, Seliverstov PV, Teterina LA. Effektivnost primeneniya prebiotika Mukofalk u patsientov s khronicheskimi zabolevaniyami pecheni i pechenochnoy entsefalopatiey na fone disbioza tolstoy kishki [The effectiveness of prebiotic Mucofalk in patients with chronic liver diseases and hepatic encephalopathy in the setting of colon dysbiosis]. SPB; 2010; 40 s. [Russian]
11. Sazonenko LV. Vyvchennia lipidnykh pokaznykiv syrovatky krovi u vahitnykh z preeklampsiieiu v dynamitsi likuvannia [Study of lipid parameters of blood serum in pregnant women with preeclampsia in the dynamics of treatment]. Lechebnoe delo. 2003; 1: 86–8. [Ukrainian]
12. Rybakova EV, Sidelnikov VM, Briuzgina TS. Sposob gazokhromatograficheskogo opredeleniya lipidov v kondensate vydykhaemogo vozdukha: informatsionnoe pismo [Gas chromatographic method for determining lipids in exhaled air condensate: an information letter]. Kyiv: Kyivskiy med institute; 1991. 2 s. [Ukrainian]
13. Husebye E, Hellstrom R, Midtvedt T. The role of normal microbial flora in control of small intestine motility. Microbiol Therapy. 1990; 20: 389–94.
14. Mouraa EGH, Domingosa TA, Alvaradoa H, Iriya K, Kishib HS, Martinsa BC, et al. Pólipo hiperplásico con transformación neoplásica en paciente con gastritis atrófica y múltiples tumores neuroendocrinos [Hyperplastic polyp with neoplastic transformation in a patient with atrophic gastritis and multiple gastric neuroendocrine tumors.]. Revista de Gastroenterología de México. 2012 Apr-Jun; 77(2): 96–8. [Spanish] https://www.ncbi.nlm.nih.gov/pubmed/22658549. https://doi.org/10.1016/j.rgmx.2012.03.002
15. Thun MJ, Henley SJ, Patrono C. Nonsteroidal anti–inflammatory drugs as anticancer agents: Mechanistic, pharmacolgic, and clinical issues. Journal of the National Cancer Institute. 2002; 94: 252–66. https://www.ncbi.nlm.nih.gov/pubmed/11854387. https://doi.org/10.1093/jnci/94.4.252
16. Wachtershauser A. Rationale for the luminal provision of butyrate in intestinal diseases. European Journal of Nutrition. 2000; 39(4): 164-71.
17. Buyukasik K, Sevinc MM, Gunduz UR, Ari A, Gurbulak B, Toros AB, et al. Upper gastrointestinal tract polyps: what do we know about them? Asian Pac Journal Cancer Prev. 2015; 16(7): 2999-3001.