The last decades in maxillofacial surgery and surgical dentistry are marked by the fact that one of the most popular and frequently encountered research topics is the pathology of the salivary glands. Patients with this pathology make up 2.3-5.2% of the total number of persons hospitalized during the year in specialized inpatient departments. The spectrum of these diseases is wide and includes: malformations, traumatic injuries, inflammatory processes of both viral and bacterial nature, reactive dystrophic lesions, salivary stone disease, benign and malignant neoplasms. Sialoadenitis can occur in both acute and chronic forms. At the same time, the ways of penetration of the infectious agent were determined: hematogenic, lymphogenic, contact, intraductal. The most frequently diagnosed inflammatory pathology of the salivary glands is chronic sialoadenitis. The purpose of the study is to identify unsolved problems and determine the directions of further research based on the analysis of available domestic and foreign specialized literature on epidemiology, diagnosis and differential diagnosis of chronic sialoadenitis. Materials and methods. The analysis of specialized literature containing information on the epidemiology, diagnosis and differential diagnosis of chronic sialoadenitis was carried out. The article analyzes periodicals for the last 10 years, as well as basic manuals, monographs, and textbooks without a statute of limitations. The descriptive method is used for the analysis. Results and discussion. Chronic sialoadenitis and sialosis account for 42.0-54.4% of the total pathology of the salivary glands. This is due to: an increase in the number of neoplasms, including malignant ones both in the maxillofacial region and in the salivary glands; an increase in the number of patients with thyroid diseases who use radioactive iodine for therapeutic purposes, which also accumulates in the salivary glands, which causes the appearance of symptoms of xerostomia and sialoadenitis; a significant share of publications indicating the complexity of the differential diagnosis of chronic sialoadenitis and a large number of diagnostic errors. Conclusion. The presented material proves that the task of developing diagnostic and differential-diagnostic tests used in chronic sialoadenitis is socially significant and belongs to the category of priority and determines the need for its early effective solution. The development and implementation of new diagnostic and differential-diagnostic tests developed and scientifically based on the principles of evidence-based medicine, used in patients with chronic sialoadenitis, will reduce the number of complications, improve the quality of life of patients, and increase the level of specialized medical care to the population

Keywords: diagnosis, differential diagnosis, chronic sialoadenitis, salivary glands

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1. Gurbanov TV. Sovremennyj vzgljad na hronicheskie vospalitel'nye i reaktivno-distroficheskie zabolevanija sljunnyh zhelez [Modern view on chronic inflammatoric and reactive-dystrophic diseases of the salivary glands]. Sovremennaya stomatologiya. 2017; 4: 2-7. [Russian]
2. Orehov SN, Matveev SV, Karakjan AJe, Ibragimova JeZ. Prichiny narushenija sekrecii sljunnyh zhelez i sposoby lechenija [Causes of impaired salivary gland secretion and treatment methods]. Sci Review. Medical Sci. 2017; 4: 58-64. [Russian]
3. Elovikova TM, Grigor'ev SS. Sljuna kak biologicheskaja zhidkost' i ee rol' v zdorov'e polosti rta: uchebnoe posobie [Saliva as a biological fluid and its role in oral health: textbook]. Yekaterinburg: Publishing house "CIRCULATION"; 2018. [Russian]
4. Afanas'ev VV, Abdusalamov MR, Bogatov VV, Bekreev VV, Belolapotkova AV, Derjabin EI, et al. Hirurgicheskaja stomatologija: uchebnik [Surgical dentistry: textbook]. M: GEOTAR-Media; 2016. [Russian]
5. Panin AM. Hirurgicheskaja stomatologija. Vospalitel'nye i distroficheskie zabolevanija sljunnyh zhelez: uchebnoe posobie [Surgical dentistry. Inflammatory and dystrophic diseases of the salivary glands: a textbook]. M: Publishing house "Litterra"; 2020. [Russian]
6. Ugga L, Ravanelli M, Pallottino AA, Farina D, Maroldi R. Diagnostic work-up in obstructive and inflammatory salivary gland disorders. Acta Otorhinolaryngol (Italy). 2017; 37(2): 83-93. https://www.ncbi.nlm.nih.gov/pubmed/28516970. https://www.ncbi.nlm.nih.gov/pmc/articles/5463527. https://doi.org/10.14639/0392-100X-1597
7. Shayahmetov D, Yuldashev I, Alzhanova A., Kasenova N. Jepidemiologicheskie issledovanija rasprostranennosti hronicheskih form sialoadenitov [Epidemiological studies of the prevalence of chronic forms of sialiadenitis]. Probl of Modern Sci and Edu. 2016; 54(12): 128-32. [Russian]
8. Sadrislamova AR, Korjagin VS. Anatomija i patologija sljunnyh zhelez. Sialoadenit, sialoz [Anatomy and pathology of the salivary glands. Sialoadenitis, sialosis]. Young Sci. 2021; 361(19): 69-71. [Russian]
9. Brezgina AA. Klinika, diagnostika i lechenie hronicheskih recidivirujushhih sialoadenitov [Clinic, diagnosis and treatment of chronic recurrent sialoadenitis]. Problems of Dentistry. 2006; 2: 7-10. [Russian]
10. Runova NB. Sovremennye principy diagnostiki i lechenija zabolevanij sljunnyh zhelez [Present-day principles of diagnosis and treatment of salivary gland diseases]. Modern Technology in Med. 2011; 3: 152-6. [Russian]
11. Kessler AT, Bhatt AA. Review of the major and minor salivary glands, part 1: anatomy, infectious, and inflammatory processes. J Clin Imaging Sci. 2018; 8: 47. https://www.ncbi.nlm.nih.gov/pubmed/30546931. https://www.ncbi.nlm.nih.gov/pmc/articles/6251248. https://doi.org/10.4103/jcis.JCIS_45_18
12. Iordanishvili AK, Zhmud MV, Lobeyko VV, Ryzhak GA. Nekotorye aspekty diagnostiki sialolitiaza v stomatologicheskih lechebno-profilakticheskih uchrezhdenijah [Some aspects of diagnostics sialolithiasis in stomatologic medial-professional ilatichesky establishments]. Biomed J Midline Ru. 2012; 13: 726-34. [Russian]
13. Erkul E, Gillespie MB. Sialendoscopy for non‐stone disorders: The current evidence. Laryngoscope Investig Otolaryngol. 2016; 5(1): 140-5. https://www.ncbi.nlm.nih.gov/pubmed/28894810. https://www.ncbi.nlm.nih.gov/pmc/articles/5510257. https://doi.org/10.1002/lio2.33
14. Lommen J, Schorn L, Roth B, Naujoks Ch, Handschel J, Holtmann H, et al. Sialolithiasis: retrospective analysis of the effect of an escalating treatment algorithm on patient-perceived health-related quality of life. Head Face Med. 2021; 17(1): 8. https://www.ncbi.nlm.nih.gov/pubmed/33648547. https://www.ncbi.nlm.nih.gov/pmc/articles/7919083. https://doi.org/10.1186/s13005-021-00259-1
15. Kochurova EV, Nikolenko VN, Kochurov VA. Sovremennye podhody k diagnostike i kompleksnomu lecheniju novoobrazovanij cheljustno-licevoj oblasti [Current approaches to diagnostics and comprehensive treatment of tumors of the maxillofacial region]. Rus J Oncolog. 2017; 22(2): 101-6. [Russian]. https://doi.org/10.18821/1028-9984-2017-22-2-101-106
16. Rosen EB, Palin ChL, Huryn JM, Wong RJ. The role of maxillofacial prosthetics for the surgically treated patient at NCI-designated comprehensive cancer centers. Laryngoscope. 2019; 129(2): 409-14. https://www.ncbi.nlm.nih.gov/pubmed/30247745. https://www.ncbi.nlm.nih.gov/pmc/articles/6344240. https://doi.org/10.1002/lary.27330
17. Svetlickij PV, Aedinova IV, Volkova VL. Atipichnoe metastazirovanie pri rake okoloushhnoj sljunnoj zhelezy [Atypical metastasis in parotid salivary gland cancer]. Int J Appl Sci Found Res. 2015; 12(3): 459-62. [Russian]
18. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, Eds. Tumours of salivary glands. In: WHO classification of head and neck tumours. Lyon: IARC; 2017. p. 159-202.
19. Hellquist H, Paiva-Correia A, Poorten VV, Quer M, Hernandez-Prera JC, Andreasen S, et al. Analysis of the clinical relevance of histological classification of benign epithelial salivary gland tumours. Adv Ther. 2019; 36(8): 1950-74. https://www.ncbi.nlm.nih.gov/pubmed/31209701. https://www.ncbi.nlm.nih.gov/pmc/articles/6822986. https://doi.org/10.1007/s12325-019-01007-3
20. Lobeyko VV, Iordanishvili AK. Luchevye sialoadenopatii u pozhilyh i staryh ljudej i ih lechenie [Ray sialoadenopaty in older people and their treatment]. Bull Ru. Military Med Academy. 2014; 45(1): 75-9. [Russian]
21. Bichev RO, Gayduk IV, Panin AM, Mkrtumyan AM, Vartanyan KF, Kirienko SL, et al. Sialoadenit na fone terapii radioaktivnym jodom (Obzor literatury. Opisanie klinicheskogo sluchaja) [Sialadenitis during therapy with radioactive iodine-131. (Reviw of the literature. A case report)]. Rus Dentistry. 2015; 8(4): 19-24. [Russian]. https://doi.org/10.17116/rosstomat20158419-24
22. De la Vieja A, Riesco-Eizaguirre G. Radio-iodide treatment: from molecular aspects to the clinical view. Cancers (Basel). 2021; 13(5): 995. https://www.ncbi.nlm.nih.gov/pubmed/33673669. https://www.ncbi.nlm.nih.gov/pmc/articles/7957486. https://doi.org/10.3390/cancers13050995
23. Upadhyaya A, Meng Zh, Wang P, Zhang G, Jia Q, Tan J, et al. Effects of first radioiodine ablation on functions of salivary glands in patients with differentiated thyroid cancer. Medicine. 2017; 96(25): e7164. https://www.ncbi.nlm.nih.gov/pubmed/28640094. https://www.ncbi.nlm.nih.gov/pmc/articles/5484202. https://doi.org/10.1097/MD.0000000000007164
24. Glazunov OA, Boiko GG, Amer AA. Sostojanie sljunnyh zhelez i slizistoj obolochki polosti rta pri porazhenii shhitovidnoj zhelezy u lic promyshlennogo regiona [The state of salivary glands and oral mucous membrane at the affection of thyroid gland in the patients from industrial region]. Innovations in Dentistry. 2013; 1: 18-21. [Russian]
25. Denisov AB. Sljuna i sljunnye zhelezy [Saliva and salivary glands]. M: RAMS; 2006. [Russian]
26. Vasilyev VI, Sokol EV, Rodionova EB, Palshina SG, Aleksandrova EN, Radenska-Lopovok SG, et al. Svjazannye s IgG4 porazhenija sljunnyh zhelez [IgG4-related salivary glands lesions]. Therapeutic Arch. 2015; 87(8): 92-102. [Russian]. https://doi.org/10.17116/terarkh201587892-102
27. Alekseenko SA, Koltunov AS, Koltunov SS, Segida MA. Klinicheskij sluchaj IgG4-associirovannogo sialoadenita [A case report of IgG4-related sialoadenitis]. Far Eastern Med. J. 2017; 3: 93-6. [Russian]
28. Zykova A, Novikov P, Brovko M, Akulkina LA, Moiseev SV. IgG4-associirovannoe zabolevanieZh chto izmenilos' k 2020 godu [IgG4-related disease: the state of art]. Clin Pharmacol Ther. 2019; 29(3): 4-13. [Russian]. https://doi.org/10.32756/0869-5490-2020-3-4-13
29. Puxeddu I, Capecchi R, Carta F, Tavoni AG, Migliorini P, Puxeddu R. Salivary gland pathology in IgG4-related disease: a comprehensive review. J Immunol Res. 2018 Apr 1; 2018: 6936727. https://www.ncbi.nlm.nih.gov/pubmed/29805984. https://www.ncbi.nlm.nih.gov/pmc/articles/5901485. https://doi.org/10.1155/2018/6936727
30. Vasilenko VV, Vinogradov DL, Burlakova AS. IgG4-soprjazhennaja patologija: sostojanie problem [IgG4-relatd disease: condition of the problem]. Rus Arch Internal Med. 2017; 7(2): 95-106. [Russian]. https://doi.org/10.20514/2226-6704-2017-7-2-95-106
31. Torgashina AV. Differencial'naja diagnostika bakterial'nogo sialoadenita v praktike revmatologa: opisanie klinicheskogo sluchaja [Differential diagnosis of bacterial sialadenitis in a rheumatologist’s practice: a case report]. J Modern Rheumatol. 2019; 13(1): 86-90. [Russian]. https://doi.org/10.14412/1996-7012-2019-1-86-90
32. Wang M, Zhang P, Lin W, Fei Y, Chen H, Li J, et al. Differences and similarities between IgG4-related disease with and without dacryoadenitis and sialoadenitis: clinical manifestations and treatment efficacy. Arthritis Res Ther. 2019; 21: 44. https://www.ncbi.nlm.nih.gov/pubmed/30709411. https://www.ncbi.nlm.nih.gov/pmc/articles/6359790. https://doi.org/10.1186/s13075-019-1828-8
33. Bychkov DV, Alyoshkin IG, Batoroyev YuK, Kazimirsky VA, Kekidze SYu, Khabudayeva IA, et al. Problemy klinicheskoj diagnostiki opuholej sljunnyh zhelez [Problems in clinical diagnostics of salivary tumors]. Siberian Sci Med J. 2016; 3: 58-61. [Russian]
34. Brennan PA, Davies B, Poller D, Mead Z, Bayne D, Puxeddu R, et al. Fine needle aspiration cytology (FNAC) of salivary gland tumors: Repeat aspiration provides further information in cases with an unclear initial cytological diagnosis. Br J Oral-Maxillofac Surg. 2010; 48: 26-9. https://www.ncbi.nlm.nih.gov/pubmed/19233526. https://doi.org/10.1016/j.bioms.2008.12.014
35. Lastovka AS, Dudareva IV, Navosha SA. Vospalitel'nye zabolevanija sljunnyh zhelez: ucheb.-metod. posobie [Inflammatory diseases of the salivary glands: textbook]. Minsk: BSMU; 2015. [Russian]
36. Ludchik TB, Gurbanov TV. Analiz jepidemiologii hronicheskih sialoadenitov i reaktivno-distroficheskih zabolevanij sljunnyh zhelez [Analysis of the epidemiology of chronic sialoadenitis and reactive dystrophic diseases of the salivary glands]. New methods of prevention, diagnosis and treatment in dentistry: a collection of materials of the Republic. Sc. and Pract Conf with Internat Participat "Complex rehabilitation of patients in the clinic of orthopedic dentistry", dedicated to the 50th anniversary of the Department of Orthopedic Dentistry of the BSMU. Minsk; 2017 Sep 29. 2017. p. 257-61. [Russian]
37. Mokhort TV, Kolomiets ND, Petrenko SV, Fedorenko EV, Mokhort AG. Dynamic monitoring of iodine sufficiency in Belarus: results and problems. Problems of Endocrinology. 2018; 64(3): 170-9. [Russian]. https://doi.org/10.14341/probl8686
38. Petrenko SV, Leushev BJ, Gulyaeva LS, Nikitin DA, Laptenok SA. Se, I, Fe, and Zn supply in population of various ecological regions of the Republic of Belarus with high incidence of thyroid disorders. Ecology. 2018; 4: 109-18. [Russian]
39. Koritko SS, Hmara IM, Salko OB, Antsipau VV. Bolezni jendokrinnoj sistemy v Belarusi – statisticheskoe i demograficheskoe sopostavlenija [Endocrine discorders in Belarus – statistical and demographic comparisons]. Me. News. 2013; 3: 42-8. [Russian]
40. Jakubovskij SV. Zabolevanija shhitovidnoj i okoloshhitovidnyh zhelez: ucheb.-metod. posobie [Diseases of the thyroid and parathyroid glands: textbook]. Minsk: BSMU; 2018. [Russian]