Antioxidant defense is considered in the context of a universal system, which, together with the components of the immune system, provides hemodynamic balance and antigenic homeostasis of the body, that is, the work of this system, represented by two practically independent links. The first line of the antioxidant system, the work of which is associated with the activity of superoxide dismutase, catalase, ceruloplasmin and a number of other enzymatic and non-enzymatic components, is considered an initial barrier, provides support at a constant controlled level of free radical oxidation. However, there is insufficient data in previous studies regarding the antioxidant defense system in patients with gastrointestinal disorders associated with thyroid disease. The purpose of the work was to establish the state of the antioxidant system in terms of total antioxidant activity and 8-isoprostane in young people with gastroesophageal reflux disease and autoimmune thyroiditis. Material and methods. The work involved 120 people with a combined course of gastroesophageal reflux disease and autoimmune thyroiditis at the age from 18 to 25 years. All patients had the same social status (students), which made it possible to equalize both physical and emotional stress, peak and stressful situations. Results and discussion. We examined the indicators of total antioxidant activity: the aggregate value of enzymes of the first level of the antioxidant system and 8-isoprostane, the level of the non-enzymatic link in antioxidant protection. These indicators depended on the morphological form of damage to the mucous membrane of the esophagus: they were more expressive in the erosive form of esophagitis. Thus, the combined course of gastroesophageal reflux disease and autoimmune thyroiditis is accompanied by changes in the indicators of the antioxidant system as a result of an active inflammatory process in the esophageal mucosa. There is a decrease in the total antioxidant activity, the first line of the antioxidant system, the value of which depends on morphological changes in the esophageal mucosa. Conclusion. An active inflammatory process in patients with gastroesophageal reflux disease and autoimmune thyroiditis leads to an increase in 8-isoprostane, an indicator of a non-enzymatic link in the antioxidant defense system

Keywords: gastroesophageal reflux disease, autoimmune thyroiditis, pathogenesis, antioxidant system

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1. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012; 5(1): 9-19. https://doi.org/10.1097/WOX.0b013e3182439613
2. Li B, Pratt DA. Methods for determining the efficacy of radical-trapping antioxidants. Free Radic Biol Med. 2015; 82: 187-202. https://doi.org/10.1016/j.freeradbiomed.2015.01.020
3. Ferreira CA, Ni D, Rosenkrans ZT, Cai W. Scavenging of reactive oxygen and nitrogen species with nanomaterials. Nano Res. 2018; 11(10): 4955-4984. doi:10.1007/s12274-018-2092-y
4. Collin F. Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases. Int J Mol Sci. 2019; 20(10): 2407. https://doi.org/10.3390/ijms20102407
5. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017; 2017: 8416763. https://doi.org/10.1155/2017/8416763
6. Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015; 2015: 760689. https://doi.org/10.1155/2015/760689
7. Koppel N, Maini Rekdal V, Balskus EP. Chemical transformation of xenobiotics by the human gut microbiota. Science. 2017; 356(6344): eaag2770. https://doi.org/10.1126/science.aag2770
8. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2016; 15(1): 71. https://doi.org/10.1186/s12937-016-0186-5
9. Jeeva JS, Sunitha J, Ananthalakshmi R, Rajkumari S, Ramesh M, Krishnan R. Enzymatic antioxidants and its role in oral diseases. J Pharm Bioallied Sci. 2015; 7(Suppl 2): S331-S333. https://doi.org/10.4103/0975-7406.163438
10. Sun MS, Jin H, Sun X, Huang S, Zhang FL, Guo ZN, et al. Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxid Med Cell Longev. 2018; 2018: 3804979. https://doi.org/10.1155/2018/3804979
11. Domej W, Oettl K, Renner W. Oxidative stress and free radicals in COPD--implications and relevance for treatment. Int J Chron Obstruct Pulmon Dis. 2014; 9: 1207-1224. https://doi.org/10.2147/COPD.S51226
12. Herasymchuk NM. 8-isoprostane as the main marker of oxidative stress. Zaporozhye medical journal. 2018; 20(6): 853-859. https://doi.org/10.14739/2310-1210.2018.6.146780
13. Voynow JA, Kummarapurugu A. Isoprostanes and asthma. Biochim Biophys Acta. 2011; 1810(11): 1091-1095. https://doi.org/10.1016/j.bbagen.2011.04.016
14. Schöttker B, Xuan Y, Gào X, Anusruti A, Brenner H. Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study. Diabetes Care. 2020; 43(1): 130-136. https://doi.org/10.2337/dc19-1379
15. Miller E, Morel A, Saso L, Saluk J. Isoprostanes and neuroprostanes as biomarkers of oxidative stress in neurodegenerative diseases. Oxid Med Cell Longev. 2014; 2014: 572491. https://doi.org/10.1155/2014/572491
16. van der Plas A, Pouly S, de La Bourdonnaye G, Baker G, Lüdicke F. Influence of smoking on levels of urinary 8-iso Prostaglandin F2α. Toxicol Rep. 2018; 6: 18-25. https://doi.org/10.1016/j.toxrep.2018.11.011