ISSN 2415-3060 (print), ISSN 2522-4972 (online)
  • 13 of 50
JMBS 2018, 3(7): 74–83
Clinical Medicine

Variability and Respiration Pattern of Patients with Persistent Asthma and Obesity

Bazhora Ya. I., Romanchuk O. P.

Obesity significantly increases the risk of different pathologies development. Prevalence of obesity and bronchial asthma increases at a parallel pace, and the presence of obesity increases the risk of bronchial asthma aggravation. The purpose of the study was to determine the peculiarities of the variability and pattern of breathing in patients with persistent asthma and obesity. Materials and methods. The complex polyfunctional method of cardiopulmonary system research – spiroarteriocardiorhythmography was used. We examined 86 women and men aged 41.0±0.8 and divided them into 4 groups. The main group consisted of 20 persons (8 men and 12 women) with clinically confirmed persistent asthma and obesity (BMI> 30 kg / m2). The first group of comparison (GC1) included 15 persons with a persistent course of asthma and BMI 25.1–29.9 kg/m2. The second (GC2) comparison group included 24 patients with a persistent flow of asthma and BMI up to 25.0 kg/m2. The control group (CG) included 10 persons, who had an intermittent course of asthma combined with obesity. Spectral analysis of respiration variability was conducted in three frequency ranges, after which the indicators of the pattern of respiration were analyzed. Spectral analysis of respiration variability was conducted in three frequency bands. According to ultrasonic spirometry, the parameters of the respiration pattern – respiration volume (RV, l), volume of inhalation and exhalation velocity were determined – RV / Tinh (l / s), and RV / Texh (l / sec), the ratio of the inhalation and exhalation phases of Tinh / Texh, and also the minute volume of breath – MRV, l. Results and discussion. Bronchial asthma patients had certain morphometric features, including those in chest, e.g. its girth was significantly bigger in MG patients. This proves formation of emphysema-like chest type. Body length and hips girth indexes were less significant. In MG patients, function of external respiration had a more pronounced manifestation of both restrictive and obstructive disorders. The differences in inspiration were significant and on exhalation their significance was more pronounced. FVC in GC1, GC2 and CG were bigger than VC. Indicators of FEV1 / FER on the inspiration in all groups corresponded to normative values. RV in patients with asthma’s persistent flow and obesity decreased. the TPD, (l/min)2 was significantly lower. Conclusions. Obesity significantly affects the regulatory provision of uncontrolled respiration with inhibition of vegetative effects, metabolic disorders, and reorganization of the pattern of breathing with the emergence of obstructive and restrictive components.

Keywords: uncontrolled breathing, persistent flow of bronchial asthma, obesity

Full text: PDF (Ukr) 647K

  1. Marchenko VN, Trofimov VI, Aleksandrin VA, Fedoseev GB. Nejrovegetativnaja reguljacija kardiorespiratornoj funkcional'noj sistemy u bol'nyh bronhial'noj astmoj [Neurovegetative regulation of cardiorespiratory functional system in patients with bronchial asthma]. Vestnik sovremennoj klinicheskoj mediciny. 2010; 3(3): 26-9. [Russian]
  2. Panenko AV, Romanchuk OP. (). Do pitannya doslіdzhennya vіkovih osoblivostej varіabel'nostі dihannya [To the question of age-related characteristics of breathability variability]. Odeskyi medychnyi zhurnal. 2004; 5: 63-6. [Ukrainian]
  3. Romanchuk AP, Noskin LA, Pivovarov VV, Karganov MYu. (). Kompleksnyiy podhod k diagnostike sostoyaniya kardiorespiratornoy sistemyi u sportsmenov [Complex approach to the diagnosis of the cardiorespiratory systems state in athletes]. Оdessa: Feniks; 2011. 256 p. [Russian].
  4. Zaporozhan VN. (). Faktory i mehanizmy sanogeneza [Factors and mechanisms sanogenesis]. Odessa: ONMU; 2014. 448 p. [Russian].
  5. Shafransky VV. Factory ryzoku rozvitky neifectsiynukh zakhvoruvan. Visnik morskyi mediciny. 2015; 3(68): 3-10 [Ukrainian]
  6. Adeyeye OO, Ogbera AO, Ogunleye OO, Brodie-Mens AT. Understanding asthma and the metabolic syndrome - a Nigerian report. Int Archives Medicine. 2012; 5(1): 20-5.
  7. Agrawal A, Mabalirajan U, Ahmad T, Ghosh B. Emerging interface between metabolic syndrome and asthma. American journal of respiratory cell and molecular biology. 2011; 44(3): 270–5.
  8. Barros R, Moreira P, Padrгo P. Obesity increases the prevalence and the incidence of asthma and worsens asthma severit. Clinical Nutritio. 2017; 36(4): 1068–74.
  9. Beigh SH, Jain S. Prevalence of metabolic syndrome and gender differences. Bioinformation. 2012; 8(13): 613–6.
  10. Berg CM, Thelle DS, Rosengren A, Lissner L, Toren K, Olin AC. Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX. Chest. 2011; 139(5): 1109–16.
  11. Boulet LP. Asthma and obesity. Clinical & Experimental Allergy. 2013; 43(1): 8–21.
  12. Brumpton BM, Camargo CA Jr, Romundstad PR, Langhammer A, Chen Y, Mai XM. Metabolic syndrome and incidence of asthma in adults: the HUNT study. Europ Respiratory J. 2013; 42(6): 1495–502.
  13. Chen YC, Dong GH, Lin KC, Lee YL. Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. Obesity Reviews. 2013; 14(3): 222– 31.
  14. Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2010; 375(9710): 181–3.
  15. Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003–2006. National health statistics reports. 2009; 13: 1–7.
  16. Frey U, Latzin P, Usemann J, Maccora J, Zumsteg U, Kriemler S. Asthma and obesity in children: current evidence and potential systems biology approaches. Allergy. 2015; 70(1): 26–40.
  17. Galisteo M, Duarte J, Zarzuelo A. Effects of dietary fibers on disturbances clustered in the metabolic syndrome. Journal of nutritional biochemistry. 2008; 19(2): 71–84.
  18. Global strategy for asthma management and prevention, 2018 [digital resource]. Available from: Last access: 2018.
  19. Gregg EW, Shaw JE. Global health effects of overweight and obesity. New England Journal of Medicine. 2017; 377(1): 80–1.
  20. Gross B, Pawlak M, Lefebvre P, Staels B. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD. Nature Reviews Endocrinology. 2017; 13(1): 36–49.
  21. Karemaker JM. An introduction into autonomic nervous function. J Physiol. 2017; 595(6): 2197–8.
  22. Lee EJ, In KH, Ha ES, Lee KJ, Hur GY, Kang EH. Asthma-like symptoms are increased in the metabolic syndrome. Journal of asthma: official journal of the Association for the Care of Asthma. 2009; 46(4): 339–42.
  23. Lehrer PM, Vaschillo EG, Vaschillo B, Lu S-E, Scardella A, Siddique M, Habib RH. Biofeedback treatment for asthma. Chest. 2004; 126(2), 352–61.
  24. Lugogo NL, Kraft M, Dixon AE. Does obesity produce a distinct asthma phenotype. J Applied Physiology. 2010; 108(3): 729–34.
  25. Mosen DM, Schatz M, Magid DJ, Camargo CA Jr. The relationship between obesity and asthma severity and control in adults. Journal of allergy and clinical immunology. 2008; 122(3): 507–11.
  26. Novosad S, Khan S, Wolfe B, Khan A. Role of obesity in asthma control, the obesity-asthma phenotype. Journal of allergy. 2013; 2013: 538- 642.
  27. Pivovarov VV. Information-measuring system for functional diagnostics of nervous regulation of blood circulation. Part II. The implementation. Automation and remote control. 2011; 72(3): 671-6.
  28. Romanchuk OP, Bazhora YaI. Regulatory peculiar features of uncontrolled bronchial asthma. J. Education, Health and Spotr. 2018; 8(1), 330-46.
  29. Romanchuk AP, Guzii OV. Respiration variability of athletes after competition load. Rev Bras Med Esporte. 2018; 24(5 Suppl.1): 78.
  30. Schwartz MW, Seeley RJ, Zeltser LM, Drewnowski A, Ravussin E, Redman LM, Leibel RL. Obesity pathogenesis: an endocrine society scientific statement. Endocrine Reviews. 2017; 38(4): 267–96.
  31. Scott R, Donoghoe M, Watts GF, O'Brien R, Pardy C, Taskinen MR. Impact of metabolic syndrome and its components on cardiovascular disease event rates in 4900 patients with type 2 diabetes assigned to placebo in the FIELD randomised trial. Cardiovascular diabetology. 2011; 10: 102-9.
  32. Singh S, Prakash YS, Linneberg A, Agrawal A. Insulin and the lung: connecting asthma and metabolic syndrome. Journal of allergy. 2013; 2013: 627384.
  33. Thuesen BH, Husemoen LL, Hersoug LG, Pisinger C, Linneberg A. Insulin resistance as a predictor of incident asthma-like symptoms in adults. / Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2009; 39(5): 700–7.
  34. Wood LG. Asthma in the obese: a big and growing problem. American Journal of Respiratory and Critical Care Medicine. 2017; 195(1): 4-5.