Microbial colonization or infection is one of the main causes of exacerbation of chronic obstructive pulmonary disease. The transition of obstructive pulmonary disease from the stage of remission to exacerbation is due to a gradual increase in the number of microorganisms in the respiratory tract. The purpose of the work was to establish the nature of the microbiological spectrum of sputum in the mining industry workers with chronic obstructive pulmonary disease of professional etiology. Materials and methods. Microbiological, microscopic, statistical. Results. It has been established that gram-positive (48.9 %), gram-negative (27.6 %) microorganisms and yeast-like fungi (23.5 %) were among the microbiota isolated during the course of chronic obstructive pulmonary disease of the professional etiology. Staphylococcus aureus strains (26.7 %), Candida albicans (22.3%), Klebsiella pneumoniae (10.9 %), Escherichia coli (9.3 %), Streptococcus viridans (5.7 %) and Streptococcus viridans (5.7 %) had a significant specific gravity Staphylococcus epidermidis (5.5 %). In the structure of the species composition of microorganisms isolated from sputum in patients with chronic obstructive pulmonary disease of the professional etiology, S. aureus (29.2 %), K. pneumoniae (12.5 %) and E. coli (9.7 % ) – for chronic obstructive pulmonary disease 1; S. aureus (31.8 %), E. coli (11.9 %) and K. pneumoniae (10.6 %) – for chronic obstructive pulmonary disease 2; S. aureus (18.8 %), K. pneumoniae (9.7 %) and S. epidermidis (9.7 %) – with chronic obstructive pulmonary disease 3. Conclusion. Character of bacterial and mycotic microflora that colonizes lower standard of patients on chronic obstructive pulmonary disease of professional etiology on the stage of intensifying is related to the clinical features and weight of disease flow. It is set that quantitative correlation, as among the gram-positive, such gram-negative microorganisms of distinguished for patients with chronic obstructive pulmonary disease of professional etiology, had considerable oscillation, depending on the stage of disease flow. The stamms of gram-positive cocci appear in patients’ sputum with chronic obstructive pulmonary disease of professional etiology on more early stages of disease from relatively by the favorable disease flow. Prospects for further research. An exposure and research of pathogens features at different stages of obstructive pulmonary disease flow of professional etiology for the workers of mining industry can extend an idea about motion of inflammatory process and help in realization of adequate therapy of this disease exacerbation.
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