The article deals with definition of population and individual predictors of herpes-associated multiform erythema. It also represents the situational analysis of their impact on the emergence and development of the disease. Materials and methods. The total volume of the study was 450 patients with symptoms of herpetic lesions of the oral mucosa, perioral area of the skin and mucous other areas. The control group was compiled with people who had no signs of this disease both in the survey and in history. This group was formed on the basis of copy-steam principle. This approach allowed to comparably form (p> 0,05) in size (450 people) and gender and age-group characteristics. Results and their discussion. The results of the research showed that the most significant factor, whose presence increases the likelihood HAME is a chronic disease of the gastrointestinal tract – odds ratio OR=6,1; p =0.0001; slightly lower prognostic significance detects thyroid pathologies – OR = 3,7 (2,8-4,9), and frequent colds and diseases of the respiratory-pulmonary system (bronchitis) showed OR = 2 6 (2,0-4,3). Diseases of digestive system also reveal significant prognostic potential effect – OR = 1,8 (1,3-2,3); p = 0.0002. Taking into account these results we defined the criteria for forming high-risk for the development of HAME.
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