ISSN 2415-3060 (print), ISSN 2522-4972 (online)
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JMBS 2017, 2(1): 114–117
https://doi.org/10.26693/jmbs02.01.114
Clinical Medicine

Viscosity of the Erythrocyte’s Suspension in Patients with Heart Failure Based on Comorbidity

Pavliukovych N. D.
Abstract

Red blood cells are sensitive to the different environmental effects, therefore various pathological processes, which are based on the hypoxia, intoxication, disorders of the cellular metabolism, which are followed with the changes of their functional and morphological properties. Detection of the functional state of erythrocytes can provide some information about the origin and degree of severity of the pathological process. The aim. The article deals with the investigation of the changes of erythrocyte suspension relative viscosity in patients with heart failure, diabetes mellitus type 2 and anemia. Materials and methods. 120 patients with chronic heart failure, diabetes mellitus type 2 and anemia were involved in the investigation. They were divided into groups according to the degree of anemia severity. The control group for comparative investigations included 20 healthy individuals, whose age did not differ statistically from the average age of the patients of research groups and corresponded them in the sex distribution. The relative viscosity of the erythrocyte suspensions was determined by O.F. Pyrohova, V.D. Dzhordzhykiya (modificated by Z.D.Fedorova, M.O.Kotovschykova). Results. Anemic syndrome comorbid to chronic heart failure contributed to the decrease of the erythrocytes relative viscosity to 0,97±0,02 (1,09±0,04 in the patients of the control group). In patients with chronic heart failure and diabetes mellitus type 2 relative viscosity of the erythrocytes suspension increased to 1,38±0,02 (р<0,05) and differed statistically from patients with heart failure and anemia (р<0,05). Analysis of the change of erythrocyte suspension viscosity in patients with chronic heart failure, diabetes mellitus type 2 according to the degree of comorbid anemia demonstrated that the dynamic of its change was not equal. In patients with heart failure, diabetes and concomitant mild anemia increasing of erythrocytes relative viscosity was determined (1,68±0,03 compared to 1,38±0,02, р<0,05). Alongwith worsening of the anemia course it was found tendency to decrease of relative viscosity of the erythrocyte’s suspension (р<0,05). Conclusion. Thus, in patients with chronic heart failure with comorbid anemia it was found decrease of the relative viscosity of the erythrocyte’s suspension. In case of the combined course of heart failure, diabetes mellitus type 2 and anemia relative viscosity of the erythrocytes depends on the severity of anemic syndrome.

Keywords: heart failure, diabetes mellitus type 2, anemia, erythrocyte

Full text: PDF (Ukr) 212K

References
  1. Osochuk SS, Randarenko IG, Yarotskaya NN, Ivanova SV. Vliyaniye anemii na sostav i fiziko-khimicheskiye svoystva membran eritrotsitov. Klinicheskaya laboratornaya diagnostika. 2013; 6: 20-2.
  2. Dygay AM, Kotlovskiy MYu, Kirichenko DA, Yakimovich IYu, i dr. Zhirnyye kisloty membran eritrotsitov u zhenshchin s ishemicheskoy bolezn'yu serdtsa pri deystvii statinov. Klinicheskaya laboratornaya diagnostika. 2014; 3: 42-7.
  3. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Eur Heart J. 2016; 37 (Iss.27): 2129-200. https://doi.org/10.1093/eurheartj/ehw128
  4. American Diabetes Association. Standards of medical care in diabetes – 2016. Diabetes Care. 2016; 39 (suppl. 1); S1-S106.
  5. Kang J, Hu K, Lu W, Zhou XF, et al. Chronic intermittent hypoxia versus continuous hypoxia: Same effects on hemorheology? Clinical hemorheology and microcirculation. 2016; 63 (Iss 3): 245-55.
  6. Gyawali P, Richards RS, Hughes DL, Tinley P. Erythrocyte aggregation and metabolic syndrome. Clinical hemorheology and microcirculation. 2014; 57 (Iss1): 73-83.
  7. Kuznik B, Fine I, Maksimova O, Kustovskaya E, et al. Non-invasive method for study aggregation properties of the platelet, leukocyte, erythrocyte and hemostasis state. Journal of thrombosis and haemostasis. 2013; 11: 1188.
  8. Kaliviotis E, Dusting J, Sherwood J.M, Balabani S. Quantifying local characteristics of velocity, aggregation and hematocrit of human erythrocytes in a microchannel flow. Clinical hemorheology and microcirculation. 2016; 63 (Iss 2): 123-48.