The demographic situation in most countries of the European region, which includes Ukraine, is characterized as quite complex. Nowadays the question of the long-term effects of maternal fetoplacental insufficiency on the functioning of human body systems, in particular on the reproductive system of male offspring, remains open. It is known that negative factors during pregnancy can affect the development and existence of the individual. The purpose of the work was to study the long-term effects of fetoplacental insufficiency on the functioning of the reproductive system of adult male offspring born by mothers of different ages. Material and methods. The study was performed on healthy adult female Wistar rats, young (3 months) and mature (10 months) of reproductive age. 4 groups were formed: the 1st and the 2nd groups included intact animals of young and mature age; the 3rd and the 4th had females with experimental fetoplacental insufficiency of young and mature reproductive age. Modeling of fetoplacental insufficiency was performed by daily subcutaneous injection to females from the 12th to the 18th day of pregnancy 50% oil solution of carbon tetrachloride at a dose of 2 ml/kg body weight. We studied the state of spermatogenesis, weight of internal organs, sex hormones in mature male offspring of 3 months of age after decapitation. Results and discussion. Fetoplacental insufficiency leads to lower testosterone levels in all offspring born to mothers of different reproductive ages. The total level of estradiol remained almost unchanged, but still, in animals there was a shift in the ratio of sex hormones in the direction of hyperestrogenism. Experimental fetoplacental insufficiency in females of different reproductive ages also affected the mass of the testes, epididymis and adrenal glands in their male offspring. According to the indicators of the functional state of epididymal sperm in animals born by reproductively young females, the share of pathological forms of sperm decreased by 45%, in the offspring born by reproductively mature females with fetoplacental insufficiency decreased the number of motile sperm by 46% compared to the intact group of animals. Conclusion. The penetration of toxic substances into the mother's body leads to varying degrees of total xenobiotic load, followed by induction of neutralization reactions and the development of metabolic forms of fetoplacental insufficiency, changing the function of the endocrine system and causing adverse effects on the reproductive system. Fetoplacental insufficiency affects the reproductive function of adult male offspring born to mothers of different reproductive ages, which is manifested in a decrease in testosterone levels and deterioration of the spermogram, which in turn can lead to problems with impregnation

Keywords: fetoplacental insufficiency, mother's age, male offspring

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1. Naselennya Ukraine [Population of Ukraine]. Available from: http://database.ukrcensus.gov.ua/PXWEB2007/ukr/publ_new1/2019/publ2019.asp [Ukrainian]
2. Polis CB, Cox CM, Tunçalp Ö, McLain AC, Thoma ME. Estimating infertility prevalence in low-to-middle-income countries: an application of a current duration approach to Demographic and Health Survey data. Human Reproduction. 2017; 32(5), 1064-1074. https://doi.org/10.1093/humrep/dex025 PMid:28204493 PMCid:PMC5400046
3. Shchorichna dopovid pro stan zdorov'ya naselennya, sanitarno-epidemichnu sytuatsiyu ta rezultaty diyalnosti systemy okhorony zdorov'ya Ukrayiny [Annual report on the state of health of the population, the sanitary and epidemiological situation and the results of the health care system of Ukraine]. Ukr in-t strateg doslidzh MOZ Ukrayiny; Red PS Melnyk ta in. Kyiv: Medinform; 2018. 458 s [Ukrainian]
4. Tsiborovskyy OM. Zdorov'ya naselennya i faktory ryzyku, shcho vplyvayut na yogo stan, yak ob'yekt upravlinnya (oglyad literatury) [Public health and risk factors influencing its condition as an object of management (literature review)]. Ukrayina. Zdorov'ya natsiyi. 2015; 2(34): 13-19. [Ukrainian]
5. Makarenko MV. Mistse ta rol fetoplatsentarnoyi systemy u rozvytku syndromu zatrymky rostu ploda [The place and role of the fetoplacental system in the development of fetal growth retardation syndrome]. Abstr. Dr. Sci. (Med.). Kharkiv; 2015. 299 s. [Ukrainian]
6. Loomans EM, van Dijk AE, Vrijkotte TG, van Eijsden M, Stronks K, Gemke RJ, et al. Psychosocial stress during pregnancy is related to adverse birth outcomes: results from a large multi_ethnic community based birth cohort. European Journal of Public Health. 2013; 23(3): 485-487. https://doi.org/10.1093/eurpub/cks097 PMid:22850187
7. Vieten C, Astin J. Еffects of a mind_fulness_based intervention during preg_nancy on prenatal stress and mood: Results of a pilot study. Arch Womens Ment Health, 2008; 11: 67-74. https://doi.org/10.1007/s00737-008-0214-3 PMid:18317710
8. Barker DJ, Thornburg KL. Placental programming of chronic diseases, cancer and lifespan: a review. Placenta. 2013; 34: 841-845. https://doi.org/10.1016/j.placenta.2013.07.063 PMid:23916422
9. Burton GJ, Fowden AL, Thornburg KL. Placental origins of Chronic disease. Physiol. 2016; 96: 1509-1565. DOI: 10.1152/physrev.00029.2015 https://doi.org/10.1152/physrev.00029.2015 PMid:27604528 PMCid:PMC5504455
10. Arabin B, Baschat AA. Pregnancy: an underutilized window of opportunity to improve long-term maternal and infant health-an appeal for continuous family care and interdisciplinary communication. Front Pediatr. 2017; 5: 69. DOI: 10.3389/fped.2017.00069 https://doi.org/10.3389/fped.2017.00069 PMid:28451583 PMCid:PMC5389980
11. Matthews TJ, Hamilton BE. First births to older women continue to rise. NCHS Data Brief. 2014; 152: 1-8.
12. Yogev Y, Melamed N, Bardin R, Tenenbaum-Gavish K, Ben-Shitrit G, et al. Pregnancy outcome at extremely advanced maternal age. Am J Obstet Gynecol. 2010; 558: e551-e557. DOI: 10.1016/j.ajog.2010.07.039 https://doi.org/10.1016/j.ajog.2010.07.039 PMid:20965486
13. Patel R, Moffatt JD, Mourmoura E, Demaison L, Seed PT, Poston L, et al. Effect of reproductive ageing on pregnant mouse uterus and cervix. J Physiol. 2017; 595(6): 2065-2684. DOI: 10.1113/JP273350 https://doi.org/10.1113/JP273350 PMid:28083928 PMCid:PMC5350451
14. Yakovleva LV, Zaichenko GV, Tsypkun AG, Laryanovska YuB, Butenko IG, Deeva TV, et al. Doklinichne doslidzhennya preparativ, pryznachenykh dlya likuvannya dysfunktsiyi platsenty: metod rekomendatsiyi [Preclinical study of drugs intended for the treatment of placental dysfunction: method recommendations]. K: DFC of the Ministry of Health of Ukraine; 2009. [Ukrainian]
15. Yanovych DO, Yanovych NYe. Biotransformatsiya ksenobiotykiv i mekhanizmy yiyi regulyatsiyi [Biotransformation of xenobiotics and mechanisms of its regulation] Naukovyy visnyk LNUVMBT imeni SZ Gzhytskogo. 2011; 2(48); 305-311. [Ukrainian]
16. Korol TM. Fetoplatsentarna nedostatnist - aktualna problema medytsyny. Kliniko-etishchpatshchgenetychni kryteriyi diagnostyky, likuvannya ta profilaktyky [Fetoplacental insufficiency is an urgent problem of medicine. Clinical and genetic criteria for diagnosis, treatment and prevention]. Visnyk problem biologiyi i medytsyny. 2013; 2(99): 49-54. [Ukrainian]
17. Chedane C, Puissant H, Weil D, Rouleau S, Coutant R. Association between altered placental human chorionic gonadotrophin (hCG) production and the occurrence of cryptorchidism: a retrospective study. BMC Pediatr. 2014 Jul 26; 14: 191. https://doi.org/10.1186/1471-2431-14-191 PMid:25064170 PMCid:PMC4114795
18. Scott HM, Mason JI, Sharpe RM. Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr Rev. 2009 Dec; 30(7): 883-925. https://doi.org/10.1210/er.2009-0016 PMid:19887492
19. Seliukova NYu, Misyura KV. Osoblyvosti endokrynnoyi funktsiyi platsenty samyts riznogo viku z fetoplatsentarnoyu nedostatnistyu [Features of the endocrine function of the placenta in females of different ages with placental insufficiency]. Problemy endokrynnoyi patologiyi. 2019; 4: 130-142. [Ukrainian]. https://doi.org/10.21856/j-PEP.2019.4.18