In the spectrum of the technogenic load of the population of industrialized cities, the problem of heavy metals is in the focus of scientific research. A special role among heavy metals belongs to lead, as an intergal indicator of technogenic environmental pollution, which has a tropism for human bone tissue, the ability to accumulate and its destruction. Material and methods. Biomonitoring (in 42 patients) was carried out morbidly by specialist clinicians. A homogeneous sample of the population was formed by gender, age (from 29 to 64 years), living at least 5 years in this city and had no occupational hazards, radiological signs of osteoporosis and other risk factors for osteoporosis according to the WHO. Biomonitoring (bone tissue) was carried out at the selected population contingent, followed by analysis of the element in the biological environment and justification for preventing the development of dyslementosis in the population of technologically polluted territories. Results and discussion. Clinical and hygienic studies among residents of ecologically contrasting territories proved that the lead concentration in the bone tissue of residents of an industrial territory was significantly higher by 2.2 times (0.66±0.156 mg / kg and 0.3±0.0276 mg / kg (p <0.05)) compared with persons in the control territory. Timely preventive measures among residents of technologically developed cities will prevent the violation of mineral metabolism. Conclusion. Thus, the obtained data substantiated the feasibility of preventive measures to minimize the technogenic load of residents of industrially polluted territories. In our methodological recommendations, along with traditional legislative, technological, sanitary and technical, special attention is paid to the use of biomedical measures aimed at increasing the body's resistance to environmental factors, the effective neutralization of lead compounds in biological media and the intensification of their elimination from the body. The most important for the health of the population is the correction of nutrition, a slight deficiency in which the essential elements can be eliminated by eating foods with a high content.

Keywords: bone, lead, industrial area

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1. Osada M, Izuno T, Kobayashi M. Relationship between environmental exposure to cadmium and bone metabolism in a non-polluted area of Japan. Environ Health Prev Med. 2011; 16(6): 341-9. PMID: 21431812. PMCID: PMC3206976. https://doi.org/10.1007/s12199-010-0204-8
2. Laird E, Ward M, McSorley E, Strain JJ, Wallace J. Vitamin D and Bone Health; Potential Mechanisms. Nutrients. 2010; 2(7): 693–724. PMID: 22254049. PMCID: PMC3257679. https://doi.org/10.3390/nu2070693
3. Chen Zh, Salam MT. Living near a Freeway is Associated with Lower Bone Mineral Density among Mexican Americans. Zhanghua Osteoporos. 2015; 26(6): 1713–21. PMID: 25677718. PMCID: PMC4470808. https://doi.org/10.1007/s00198-015-3051-z
4. Smith TО, Schneider AD, Katchko KM, Chawon Н, Hsu EL. Environmental Factors Impacting Bone-Relevant. Front Endocrinol (Lausanne). 2017; 8: 22. https://doi.org/10.3389/fendo.2017.00022
5. Metody kontrolya. Khymycheskye faktory. Opredelenye khymycheskykh elementov v byologycheskykh sredakh y preparatakh metodamy atomno-emyssyonnoy spektrometryy y mass-spektrometryy s ynduktyvno svyazannoy plazmoy [Control methods. Chemical factors. Determination of chemical elements in biological media and preparations by atomic emission spectrometry and inductively coupled plasma mass spectrometry]. Metodycheskye ukazanyya MUK 4.1.1482-1483-03. M: Mynzdrav Rossyy; 2003. 56 p. [Russian]
6. Antomonov MYu. Matematycheskaya obrabotka y analyz medyko-byologycheskykh dannykh [Mathematical processing and analysis of biomedical data]. Kyev; 2017. 578 p. [Russian]
7. Erokhyn AN, Ysakov BD, Nakoskyn AN. Osobennosty mykroelementnogo sostava kostnoy tkany pry chreskostnom dystraktsyonnom osteosynteze metodom Ylyzarova v uslovyyakh vysokogorya eksperymentalnoe yssledovanye) [Peculiarities of the microelement composition of bone tissue during transosseous distraction osteosynthesis using the Ilizarov method in a high-altitude experimental study)]. Saratovskyy nauchno-medytsynskyy zhurnal. 2014; 10(1): 119-23. [Russian]
8. Roczniak W, Brodziak-Dopierała B, Cipora E. The Content of Structural and Trace Elements in the Knee Joint Tissues. Int J Environ Res Public Health. 2017; 14(12): 1441. PMID: 29168758. PMCID: PMC5750860. https://doi.org/10.3390/ijerph14121441
9. Biletska EM, Shtepa OP, Kalinicheva VV. Vyvchennya modyfikatsiyi tsynkovogo statusu laboratornykh tvaryn v umovakh nyzkodozovogo diyi svyntsyu i tsynku v riznykh formakh [Study of modification of zinc status of laboratory animals in conditions of low-dose action of lead and zinc in various forms]. Medychni perspektyvy. 2017; 22(4): 13-9. [Ukrainian] https://doi.org/10.26641/2307-0404.2017.4.117661
10. Biletska EM, Onul NM, Kalinicheva VV. Porivnyalna otsinka bioprotektornoyi diyi tsynku v organichniy ta neorganichniy formi na osteotropnist svyntsyu v eksperymentalnykh umovakh [Comparative evaluation of bioprotective effect of zinc in organic and inorganic form on lead osteotropy in experimental conditions]. Medychni perspektyvy. 2016; 21(4): 123-9. [Ukrainian] https://doi.org/10.26641/2307-0404.2016.4.91481
11. Biletska EM, Onul NM, Kalinicheva VV. Kombinovana diya nyzkodozovykh rivniv svyntsyu ta tsynku na kistkovu tkanynu shchuriv [Combined effect of low-dose levels of lead and zinc on bone of rats]. Zaporizkyy medychnyy zhurnal. 2018; 20(1(106): 101–4. [Ukrainian] https://doi.org/10.14739/2310-1210.2018.1.122121