In diabetes mellitus, which accounts for about one–third of gastroparesis cases, unpredictable carbohydrate uptake can lead to increased glycemic variability and a tendency to hypoglycemia. Exposure to gastric or extra–gastric pathogenic factors may mediate the gastroparesis symptoms' severity. The symptoms associated with gastroparesis in patients with diabetes did not correlate with glycosylated hemoglobin levels or gastroparesis severity. The relevance of this topic is the approach to the treatment of patients with diabetes mellitus type 2 and chronic gastritis requires individualization, which requires not only the detection of Helicobacter pylori and antihelicobacter therapy but also the correction of the evacuation function of the stomach. The purpose of the study was to compare the efficacy between usage of itopride hydrochloride and domperidone in patients with diabetes mellitus 2 type and chronic gastritis. Material and methods. We examined 66 Helicobacter pylori positive patients with a combination of chronic gastritis and diabetes mellitus 2 type, who were treated in the endocrinology department of the Transcarpathia Regional Clinical Hospital named after A. Novak. The patients` mean age was 56.8±2.6 years. There were 39 (59.1%) women and 27 (40.9%) men among these patients. All patients were divided into two groups. The 1st group in addition to standard antihelicobacter pylori therapy received prokinetic itopride hydrochloride while the 2nd group received domperidone. Results and discussion. The better results of the clinical manifestations dynamics in the gastrointestinal tract were obtained in the 2nd group patients with diabetes mellitus 2 type and chronic gastritis associated with the Helicobacter pylori, who were treated with the drug domperidone compared with the 1st group where patients were treated with the drug itopride hydrochloride. Higher domperidone efficacy may be associated with slower gastric emptying under its influence. Conclusion. In patients with diabetes mellitus 2 type, the gastrointestinal lesions are quite common and are manifested by the following clinical symptoms: acid belching – 40.9 %, heartburn – 28.8 %, nausea – 57.6 %, feeling of difficulty in the epigastrium – 59 %, epigastric pain – 36.4 %. When treating patients with prokinetic domperidone, we observed an improvement in their condition, namely, the number of patients' complaints regarding acid belching, heartburn, nausea, feeling of difficulty in the epigastrium, and epigastric pain decreased.
Keywords: diabetes mellitus 2 type, chronic gastritis, prokinetics
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