The article highlights the influence of the domestic metabolite ATP-long drug containing the main energy phosphate molecule in a protected form on the indicators of the red link of hematological homeostasis, including red blood cell indices, and the parameters of prooxidant-antioxidant equilibrium in erythrocyte membranes, which is of considerable interest in connection with the influence of these characteristics on the oxygen-transport function of the blood, and therefore aerobic performance during intense physical exertion. The choice of the drug was due to the fact that the energy supply of an erythrocyte, which does not have its own energy-generating system and significantly affects its functional characteristics. On the other hand, it provokes structural changes in the erythrocyte membrane, its further deformation and size changes, which makes it difficult for the cells to move along the microcirculation bed and, as a result, disrupts the ability of the oxygen transport system of the blood, thereby impairing the supply of energy and plastic substrates to the myocardium and the athlete’s skeletal muscle. Material and methods. The study was conducted in 25 athletes during 21 days of training on the formation of endurance (running at middle distances), distributed on the main (15 people) and control groups (10 people). By design, the study was shaped like a blind placebo-controlled study and included the signing by the athletes of the “Informed Consent”. For comparison, the same indicators were studied in 10 donors of the same age and gender (men 19-22 years old). Results and discussion. Determination of the effect of ATP-long drug proved that its course application improved the prooxidant-antioxidant balance in erythrocyte membranes due to both inhibition of lipid peroxidation processes and an increase in the content of reduced glutathione in the membranes, the main non-enzymatic antioxidant, which led to an increase in the content of intraerythrocyte hemoglobin and indicated the release from the depot of young forms of red blood cells (an increase in the average volume of red cells and anisocytosis). In general, this indicates an improvement in the oxygen-transport function of the blood and indirectly indicates an increase in the degree of protection of athletes’ myocardium and skeletal muscle from ischemia and hypoxia. Conclusion. The results of the study proved the feasibility and validity of the course use of the metabolite ATP-long drug with aerobic exercise to maintain the red blood cell of hematologic homeostasis and improved the oxygen-transport function of the blood of athletes.

Keywords: aerobic load, red blood cell, membrane, energy supply, prooxidant-antioxidant balance

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