The article deals with the question of determining diagnostic sensitivity of biochemical markers of blood and urine serum in patients with osteochondrosis of the lumbar spine to establish the most informative laboratory tests for the examination of patients with this pathology. Material and methods. We examined 28 patients with osteochondrosis of the lumbar spine. 7 persons aged 24 to 40 made up group 1, 5 persons (aged 42 to 49) were included in group 2, 6 persons from 53 to 59 years old were in group 3, and 10 persons aged 62 to 69 made up group 4. Among the patients, there were 8 men and 20 women. Diagnostic sensitivity (DS) of laboratory parameters was calculated using the formula DS = (TP / D) × 100%, where TP is truly positive results of the study, D – the number of patients in the group. Results and discussion. The assessment of the DS was carried out according to the following principle: DS is zero – no diagnostic sensitivity; DS from 1.0 to 50 % – diagnostic sensitivity has no definite diagnostic significance, DS from 51 to 100 % - diagnostic sensitivity is high. In patients with osteochondrosis of the lumbar spine aged 24-40, the diagnostic sensitivity of the biochemical markers of blood was as follows: glycoproteins, I fractions of GAG and HDL cholesterol – 100 %, chondroitin sulfates, II fraction of GAG, cholesterol and antherrogenic fraction – 85.7 %, acidic phosphatase – 71.4 %; in urine – diagnostic sensitivity of uronic acids – 71.4 %, calcium – 57.1 %. In patients with osteochondrosis of the lumbar spine aged 42-49, the diagnostic sensitivity of the biochemical markers of blood was the following: glycoproteins, chondroitinsulfates, acid phosphatase and atherogenicity coefficient – 100 %, II fraction of GAG – 80 %, I and III fractions GAG, HDL cholesterol – 60 %; in urine – diagnostic sensitivity of uronic acids – 100 %, oxyproline – 60 %. In patients with osteochondrosis of the lumbar spine aged 53-59, the diagnostic sensitivity of the biochemical markers of blood was as follows: chondroitin sulfates and I fraction of GAG – 100 %, glycoproteins, alkaline and acid phosphatase – 83.3 %, HDL cholesterol – 66.7 %; in the urine – the diagnostic sensitivity of oxyproline – 100 %, calcium – 66.7 %. In patients with osteochondrosis of the lumbar spine aged 62-69, the diagnostic sensitivity of the biochemical blood markers was the following: glycoproteins, chondroitinsulfates, I fraction GAG, HDL cholesterol and atherogenicity factor – 100 %; total GAG, total cholesterol and LDL cholesterol – 90 %; triglycerides and alkaline phosphatase – 80 %, β-lipoproteins and cholesterol LPDH – 70 %, II fraction GAG – 60 %; in urine – diagnostic sensitivity of oxyprolin – 100 %, creatinine – 70 %. Conclusions. Biochemical markers of blood and urine depending on the index of diagnostic sensitivity from 57.1 to 100 % can be recommended for examination of patients with osteochondrosis of the lumbar spine of different age groups. This will allow to objectively and reasonably estimate the degree of inflammatory process and destruction of connective tissue in the body of patients, and to establish lipid metabolism disorders in patients of the older age group.
Keywords: lumbar spine, osteochondrosis, age, biochemical markers, diagnostic sensitivity, informativeness
Full text: PDF (Ukr) 202K