ISSN 2415-3060 (print), ISSN 2522-4972 (online)
  • 2 of 61
Up
УЖМБС 2018, 3(5): 14–18
https://doi.org/10.26693/jmbs03.05.014
Experimental Medicine and Morphology

The Influence of Chronic Alcohol Intoxication on Blood Biochemical Indicators in Mechanical Treatment

Babkina E. P. 1, Shevchenko L. A. 2, Matiukhin D. O. 3
Abstract

Alcohol intoxication leads to an increase in both somatic diseases and mechanical injuries and becomes not only a medical but also a social problem. The importance of this problem is also connected with the fact that half of the deaths are made up of people of working age from 20 to 60 who were in the state of alcohol intoxication. A sufficiently large number of persons with chronic alcohol intoxication are among them. The purpose of the study was to develop a set of criteria to evaluate the effects of chronic alcohol intoxication on the morpho-functional state of the internal organs (liver and pancreas) with mechanical trauma biochemical blood indices. Material and methods. Research materials are medical records of 74 inpatients and ambulatory patients with chronic alcoholism, who appealed for help to the regional drug treatment clinic and 116 medical records of injured inpatients and ambulatory patients who applied to hospital. We used the following biochemical methods: a) blood chemistry: study of total protein, alanine aminotransferase, aspartate aminotransferase, glucose, cholesterol, total, direct and indirect bilirubin, alpha -amylase , b) forensic blood chemistry, urine for alcohol content. Results and discussion. The obtained results showed that the best biochemical indicators to assess the functional state of the liver, which suffers the most under the influence of chronic alcohol intoxication is alaninaminotransferase, aspartataminotransferase, total and direct bilirubin, which significantly raised during abuse of alcohol. Pathology of the pancreas was studied by the enzyme α-amylase, which were raised because of alcoholic and traumatic injuries. The biochemical parameters of blood in men were statistically significantly different among all the groups under study (p <0.05). The first group consisted of men who died not brutally though they had chronic alcohol intoxication; the second comprised the men who died from mechanical trauma having the chronic alcohol intoxication; the third – men who brutally died from a mechanical trauma. The most statistically significant differences are the characteristics of AlAT, AsAT, general and direct bilirubin, which are significantly higher in the injured men who did not drink alcohol than in men with chronic alcohol intoxication, and in men who received a mechanical injury being in the state of alcohol intoxication. In the course of the study, we found that the biochemical parameters of blood in women were statistically significantly different among all the groups under study (p <0.05). The first group consisted of women who died not brutally though they had chronic alcohol intoxication; the second comprised the women who died from mechanical trauma having the chronic alcohol intoxication; the third – women who brutally died from a mechanical trauma. The most statistically significant differences were characterized by indicators of AlAT, AsAT, general and direct bilirubin, which were significantly higher in injured women who did not drink alcohol than in women with chronic alcohol intoxication and in women who received mechanical injuries being in the state of alcohol intoxication. In the course of our research and static treatment of biochemical blood parameters using the method of multidimensional statistics (binary logistic regression method), we established the possibility of predicting the presence of chronic alcohol intoxication in the dead and those who died from mechanical trauma. We developed a mathematical model of the forecast, which allows us to assess the degree of risk of an adverse event in the injured, expressed in the overall risk indicator. To assess the adequacy of mathematical models, we used a conjugation table for the calculation of informative indicators (diagnostic sensitivity, diagnostic specificity, diagnostic efficiency, predictive value of a positive result). Conclusions. We found out that the most statistically significant differences were characterized by values of ALT, AST, total and direct bilirubin, which is significantly higher than in women with chronic alcohol intoxication, and women who received mechanical injury being in the state of alcohol intoxication than traumatized women who had been drinking. Using our binary logistic regression method enabled us to develop and effectively apply into practice a mathematical model and computer program that should be used to determine the presence of chronic alcohol intoxication in injured and people who died from mechanical trauma.

Keywords: alcohol intoxication, diagnostics, mechanical trauma, liver, pancreas, biochemical indices

Full text: PDF (Ukr) 201K

References
  1. Permyakov AV, Viter VI. Pathomorphology and tanatogenesis of alcohol intoxication. Izhevsk: Expertise, 2002. 91 p. [Russian]
  2. Denisyuk YaS. Sychasnі look at the problem of alcoholic swallows of the liver (etiology, pathogenetic mehanizmi, klіnіchnі evidivi, principle of diagnostics). Hepatology. 2009; 4: 4-15. [Ukrainian]
  3. Correale M, Laonigro I, Altomare E, Di Biase M. Alcohol-induced cardiac disease. Ital Cardiol (Rome). 2009 Jan; 10 (1): 18-27. https://www.ncbi.nlm.nih.gov/pubmed/19292016
  4. World Health Organization (2011) Global status report on alcohol and health. Geneva, Switzerland: WHO Press Library, 2011, 286 р.
  5. Stahre M, Roeber J, Kanny D, Brewer RD, Zhang X. Contribution of excessive alcohol consumption to deaths and years of potential life lost in the United States. Prev Chronic Dis. 2014; 11: E109. https://www.ncbi.nlm.nih.gov/pubmed/24967831. https://www.ncbi.nlm.nih.gov/pmc/articles/4075492. https://doi.org/10.5888/pcd11.130293
  6. Grubova LV. Clinical-functional characteristics of lesions of the hepatobiliary system in alcoholic illness in young men: Abstr. PhDr. (Med.). Ufa; 2012. 22 p. [Russian]