The achievements of modern network science in the field of molecular biology, genome, and molecular genetics made it possible to study the causes of comorbidity on the organism, molecular, genetic levels, and to show the importance of cellular networks between these components. Using these advances has led to the isolation of a particular group synthropic diseases. Chronic obstructive pulmonary disease is a classic example of a comorbid disease characterized by a combination with coronary artery disease, arterial hypertension. This causes the actuality of studying the problems of pathogenesis, comorbidity, synthropy of chronic obstructive pulmonary disease. The purpose of the study was to investigate the features of the lipid spectrum and echocardiography parameters interrelationships in chronic obstructive pulmonary disease with coronary artery disease, arterial hypertension. Material and methods. 35 patients with chronic obstructive pulmonary disease with comorbid pathology (57.14% male, 42.86% female) were examined. The average age was 57.0, the middle duration of the disease was 10.02 [5,0-15,0] years. Patients were divided into 3 groups: group B (12 patients), group C (14 patients), group D (9 patients). Results and discussion. We found 7 positive correlations with the parameters of the heart structural-functional state. Analysis of echocardiography indices revealed changes in the parameters of both the right and the left ventricle, more pronounced in the presence of comorbidity. The change in pulmonary blood flow leads to the pressure increase in the pulmonary artery, a load on the right heart, an increase in structural and functional changes in the right heart (more pronounced for comorbidity). The peculiarity of group D was a large number of correlations. With the comorbidity of chronic obstructive pulmonary disease and arterial hypertension, the total number of correlations remains. 5 correlations were revealed between the lipid spectrum and echocardiogramm: total cholesterol and aortic diameter (R=0.506), low-density lipoproteins and interventricular septum thickness, aortic root diameter, right atrium (R=0.445, 0.438, and 0.535, respectively). Conclusions: There is a significant number of various correlation links between the parameters of the lipid spectrum and the parameters of the myocardium structural-functional state. The number of correlations increases with the progression of the severity of chronic obstructive pulmonary disease. The connection of arterial hypertension and coronary artery disease is also accompanied by an increase in the number of correlations and their nature: in coronary artery disease, there are 6 such links, without it – 4; with arterial hypertension there are 8 correlations, without it there are only 6. The revealed correlations reflect the relationship between lipids and myocardial remodeling in chronic obstructive pulmonary disease. Correlation analysis suggests that the obtained data reflect the interactions of various nodes of the disease network and can be evaluated as signs of the synthropy of chronic obstructive pulmonary disease, arterial hypertension and atherosclerosis.
Keywords: comorbidity, chronic obstructive pulmonary disease, echocardiography, synthropy
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