The purpose of the study is to examine morphological changes of mucosa of rats’ colon under the influence of monosodium glutamate (MSG). Materials and methods. Studies were conducted on white nonlinear male rats weighing 145-180 g. In three groups, 7 rats were examined towards the effect of 10, 20 and 30-day usage of sodium glutamate at a dose of 30 mg/kg once daily, orally (corresponding to 2 g/animal). Research results. After 10 days of GH usage in rats, mucous membranes were found a moderate polymorphic-cellular infiltration; hyperfluid, stasis of erythrocytes in vessels. After 20 days of GH usage in the epithelial cells of the mucosa, dystrophic changes were observed; there was a decrease in the number of glass-shaped cells; moderate polymorphic-cell infiltration of the mucosa; fibrinous erythrocytic thrombi in the capillaries of the mucous membrane. Erosion was found in three cases. In rats after 30 days of GH use marked polymorphic-cell infiltration of the mucosa; fibrinous erythrocytic thrombi in the vessels. In one case, the ulcer was found in the gut wall. In two cases, signs of moderate dysplasia of the glands of the mucus have been found, and in one case, pronounced dysplasia with the formation of flat tubular adenoma. Conclusions. Long-term daily MSG usage even in safe doses leads to morphological changes in the colon wall in the form of focal inflammatory changes in the mucous membrane, disorders of the circulatory system in the intestine wall, erosive and ulcerative lesions, as well as dysplastic changes, which may be dangerous in terms of potentiation of carcinogenesis in the mucous membrane of the large intestine.

Keywords: large intestine, sodium glutamate, morphological changes

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